Skip to main content
OpenTrials
Completed

NCT Number: NCT00928954

Cross-over Comparison of Gabapentin and Memantine as Treatment for Acquired Nystagmus

Involuntary oscillations of the eyes (nystagmus) impairs vision so that affected patients, who have neurological disorders such as Multiple Sclerosis (MS) , cannot read or watch TV. Two medicines have been reported to suppress nystagmus and improve vision in such patients: gabapentin and memantine. The investigators set out to test which of these two drug was more effective by carrying out a double-blind cross-over study. In this way, we could determine which drug worked best in each patient.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Nystagmus Cranial Nerve Diseases Eye Diseases Nervous System Diseases Nystagmus, Pathologic Ocular Motility Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Veterans Affairs Medical Center, 10701 East Boulevard

Cleveland, Ohio, 44106, United States

About this study

The study entails careful measurements of visual acuity and precise measurements of eye movements, using a contact lens device (magnetic search coil method). In this way, it is possible to make objective and reliable measurements of the effect of each drug, which are unbiased by the investigator or the patient.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult (18 years or older) males or females with acquired nystagmus that is degrading their vision

Exclusion criteria

  • Pregnant women
  • Individuals who cannot describe their visual symptoms, cooperate with testing, or give informed consent
  • Individuals with intolerance of gabapentin or memantine

Treatment and study plan

Gabapentin

Drug

increasing to 1200 mg/day

Other names: Neurontin

Memantine

Drug

increasing to 40 mg/day

Other names: Nameda

Primary outcomes

  1. Change in logMAR Visual Acuity of Each Eye, Measured During Far or Near Viewing

    Time frame: After 2 weeks of therapy, for both drugs

  2. Percent Change in Median Eye Speed

    Time frame: After 2 weeks of therapy, for both drugs

    Median eye speed during attempted visual fixation by each eye

Sponsors and collaborators

Lead sponsor

Case Western Reserve University

Other

Registry information

Official study title

Investigation and Treatment of Ocular Motor Disorders: Cross-over Comparison of Gabapentin and Memantine as Treatment for Nystagmus

Important dates

Study start
2005
Primary completion
2009
Study completion
2009
First posted
Jun 26, 2009
Registry last updated
Jul 29, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.