Cross Modal Correlation of EEG and MRI Functional Connectivity: An Investigative Study

Cross modal correlation of EEG and MRI functional connectivity: An Investigative Study. Correlating EEG Analysis with Brain Network Connectivity in fMRI. The primary aim of this study is to correlate correlation of MRI and EEG. The expected study duration is approximately 24 months (first patient in to last patient out). Estimated Enrolment: 1500 Subjects.

The aim of this study is to correlate between fMRI and EEG. Overall, the integration of AI into the study of correlations between EEG and fMRI for brain network analysis holds great promise for advancing our understanding of brain function.

Upon consent, eligible participants will be invited for EEG evaluation. EEG will be obtained using a dry electrodes headset. Correlation between fMRI and EEG connectivity for each EEG frequency band across different configurations (brain atlas, EEG connectivity measure).

EEG data will undergo pre-processing of filtering, electrical line noise removal, artifact removal and down sampling. EEG analysis for each state, comprising within and between participant data, will include frequency analysis (peak frequency and relative power), oscillations (proportions of the activity of the alpha, beta, theta, and delta bands) and power spectra distribution. Functional connectivity analysis will be performed including functional coupling.

For evoked response potentials analysis, data will be segmented to trials/epochs. Bad trials will be excluded from analysis. Included trials data will be averaged. Event-related synchronization (ERS) / desynchronization (ERD) will be evaluated.

Inclusion criteria

• Male or females aged 18 years or older.
• Performed a brain MRI at the Sagol Center MRI Unit, at the Shamir Medical Center
• Able to cooperate in an EEG evaluation
• Can read and sign the informed consent.

Exclusion criteria

• Any scalp/bone abnormality incompatible with the EEG electrodes
• Any known allergy to metals.
• Inability to cooperate with simple instructions.
• Inability to read and sign the informed consent.