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NCT Number: NCT07328724

Critical Illness After Hematopoietic Cell Transplantation

This is a prospective, multicenter observational trial for patients who develop critical illness after hematopoietic cell transplantation. Patients who are admitted to the intensive care unit after undergoing hematopoietic cell transplantation at the participating medical centers will be enrolled in this study. The clinical characteristics, laboratory profiles, managements, and clinical outcomes will be prospectively collected.

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Key information

Conditions

Critical Illness Disease Attributes Hematopoetic Stem Cell Transplantation Pathologic Processes Pathological Conditions, Signs and Symptoms Transplant Complication Ventilated Patients

Sex eligibility

All sexes

Study type

Observational

Primary location

Peking University People's Hospital, Beijing, China

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who underwent hematopoietic cell transplantation at any of the participating medical centers.
  • Patients who are admitted to ICU for the management of critical illness following hematopoietic cell transplantation.

Exclusion criteria

  • Admitted to ICU for a reason other than critical illness (e.g., routine postoperative monitoring) and discharged within 2 days of ICU admission.
  • Unavailable in-ICU clinical outcomes or absent key baseline characteristics.
  • Any other conditions that, in the opinion of the investigator, can interfere with the interpretation of data.

Treatment and study plan

Primary outcomes

  1. Overall survival

    Time frame: Before ICU discharge; within 6 months after ICU discharge; and within 1 year after ICU discharge.

    Overall survival after admission to the intensive care unit.

Secondary outcomes

  1. Non-relapse mortality

    Time frame: Before ICU discharge; within 6 months after ICU discharge; and within 1 year after ICU discharge.

    Non-relapse mortality after ICU admission.

  2. Relapse

    Time frame: At ICU admission and within 1 year of ICU discharge.

    Disease relapse or progression at or after ICU admission.

  3. Transplant complication

    Time frame: At ICU admission and within 1 year of ICU discharge.

    Hematopoietic-cell-transplantation-associated complications at or after ICU admission.

  4. Organ failure

    Time frame: At ICU admission and within 1 year of ICU discharge.

    Organ failure occurring at or after ICU admission.

  5. Organ support therapy

    Time frame: At ICU admission and within 1 year after ICU discharge.

    The use of organ support therapy at or after ICU admission.

  6. Long-term survival data

    Time frame: Up to 5 years after ICU discharge.

    Overall survival, non-relapse mortality, and transplant-related mortality during long-term follow-up after ICU discharge.

Study contacts

Contact information is provided by the study sponsor or research team.

Peng Zhao, MD

CONTACT

[email protected]

861088324577

Xiao Hui Zhang, MD

CONTACT

[email protected]

861088324577

Sponsors and collaborators

Lead sponsor

Peking University People's Hospital

Other

Collaborators

  • Chinese Academy of Medical Sciences
  • First Affiliated Hospital of Harbin Medical University
  • First Affiliated Hospital of Zhejiang University
  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Xinqiao hospital of the third military medical university

Registry information

Official study title

Critical Illness Among Recipients of Hematopoietic Cell Transplantation (CARE-HCT): a Prospective, Multicenter Observational Study in China

Acronym: CARE-HCT

Important dates

Study start
2026
Primary completion
2036
Study completion
2036
First posted
Jan 9, 2026
Registry last updated
Jan 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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