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Enrolling by Invitation

NCT Number: NCT07179458

Criterion-learning Naming Treatment For Addressing Comprehension Deficits in Aphasia

Aphasia is a disorder of spoken and written language, most commonly following a stroke. It is estimated that between 2.5 and 4 million Americans are living with aphasia today. A common problem in aphasia involves difficulty retrieving known words in the course of language production and comprehension. The overarching goal of this project is to develop and test early efficacy, efficiency, and the tolerability of a lexical treatment for aphasia in multiple-session regimens that are comprised of retrieval practice, distributed practice, and training dedicated to the elicitation of correct retrievals. The aim of this work is to add to and refine the evidence base for the implementation and optimization of these elements in the treatment of production and comprehension deficits in aphasia, and make important steps towards an ultimate goal of self-administered lexical treatment grounded in retrieval practice principles (RPP) to supplement traditional speech-language therapy that is appropriate for People with Aphasia (PWA) from a broad level of severity of lexical processing deficit in naming and/or comprehension. This project cumulatively builds on prior work to develop a theory of learning for lexical processing impairment in aphasia that aims to ultimately explain why and for whom familiar lexical treatments work, and how to maximize the benefits they confer.

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Key information

Age range

18 year–89 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Jefferson Moss Rehabilitation Research Institute

Elkins Park, Pennsylvania, 19027, United States

About this study

This study examines a retrieval practice-based naming treatment termed criterion learning. In criterion learning, each item's assigned criterion level dictates the number of times that item is correctly retrieved before it is dropped from further training within a session. Criterion learning optimally incorporates potent learning experiences, including spaced retrieval practice with emphasis on correct retrievals during training. The present study will provide critical observations for optimizing criterion learning for treating word processing deficits in people with aphasia. This study will recruit 20 community-dwelling individuals with aphasia, who will undergo comprehensive neuropsychological characterization. Subsequently, participants will engage in an experimental treatment designed to promote improvements in word processing deficits.

This study will examine transfer from two types of naming treatment to word comprehension performance. Each PWA will perform naming treatment in one session at different dosages with a test of comprehension performance administered approximately one week and one month following treatment. Main outcomes of interest will be degree of transfer of each type of naming treatment to comprehension performance.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • English as a native or primary language
  • Adults with stroke who are at least 6 months post-onset
  • Exhibit semantic comprehension deficit, defined as a minimum of 80 errors on word-picture verification pre-test

Exclusion criteria

  • History of comorbid neurological diagnoses, such as Multiple Sclerosis or Parkinson's Disease
  • History of a learning disability that significantly impacted language development, such as developmental language disorder
  • Insufficient stamina to participate in the protocol

Treatment and study plan

Criterion-learning practice

Behavioral

The experiments will be presented on a computer. On each criterion-learning trial, a picture is presented and the participant is asked to try to produce the name for the object with or without a cue. Correct-answer feedback is provided. Criterion learning involves presenting a block of items in fixed order, and on each trial, the experimenter or a voice-recognition component will code the response during the trial as correct/incorrect. When the item reaches its assigned criterion level, it is dropped from further training in a session.

Primary outcomes

  1. Trained comprehension items

    Time frame: approximately one-week and one-month following treatment

    Word-picture verification task

Secondary outcomes

  1. Trained naming items

    Time frame: a single session held during a single day, scheduled at the participant's convenience but typically held within two weeks following pre-treatment assessment

    Confrontation naming task that involves trained items

  2. Trained comprehension items

    Time frame: pre-treatment

    Word-picture verification task

  3. Untrained comprehension items

    Time frame: pre-treatment, approximately one-week and one-month post-treatment

    Word-picture verification task

Sponsors and collaborators

Lead sponsor

Albert Einstein Healthcare Network

Other

Collaborators

  • National Institute on Deafness and Other Communication Disorders (NIDCD)
  • Thomas Jefferson University

Registry information

Official study title

Word Retrieval in Aphasia

Important dates

Study start
2024
Primary completion
2028
Study completion
2028
First posted
Sep 17, 2025
Registry last updated
Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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