Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06644196

Creation of a Database of Images of the Eye With the Holographic Doppler Laser

Many retinal pathologies are of vascular origin. In order to better understand their pathophysiology and make an accurate diagnosis, it is essential to visualise and quantify blood flow. The holographic Doppler laser (LDH) is a new medical device currently being developed by physics researchers at the Institut Langevin. The 1st prototype of this device is currently being used as part of research involving humans with minimal risks and constraints at the Hôpital National de la Vision des Quinze-Vingts (NCT04129021).

In order to better visualise, understand and quantify the vascular anomalies suspected in the fundus of patients undergoing ophthalmology treatment , we would like to acquire images/videos with a 2nd LDH prototype, within the ophthalmology clinical investigation platform at the Hôpital Fondation Adolphe de Rothschild.

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital Fondation A. de Rothschild

Paris, 75019, France

Location status: Recruiting

Location contact

Raphaël Lejoyeux, Dr

CONTACT

[email protected]

(0)148036437 ext. +33

Raphaël Lejoyeux, Dr

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For all participants:

  • Age ≥ 18 years
  • Having received informed information about the study and having signed a consent to participate in the study
  • Affiliated or beneficiary of social insurance

For participants with no known ocular pathology:

  • No known ocular pathology other than a refractive disorder

For patients with optic nerve pathology:

  • Patient undergoing ophthalmology consultation for optic nerve pathology in at least one eye (examples: glaucoma, optic neuritis, hereditary optic nerve diseases)

For patients with retinal and/or choroidal pathology:

  • Patients undergoing ophthalmology consultations for retinal and/or choroidal pathology in at least one eye (examples: diabetic retinopathy, age-related macular degeneration).

For patients with retinal vascular pathology:

  • Patient undergoing ophthalmology consultation for retinal vascular pathology in at least one eye (e.g. central retinal artery occlusion, central retinal vein occlusion, ocular ischemia syndrome).

Exclusion criteria

  • Inability to maintain a stable sitting position
  • Contraindications to holographic doppler laser :
  • implanted medical electronic device (pacemaker or other)
  • history of photosensitivity.
  • received photo-dynamic therapy (PDT) within the last 3 months.
  • viral conjunctivitis or any other infectious disease.
  • skin lesions on the neck or forehead, not allowing contact with a chin strap
  • patients at high risk of damage from optical radiation (e.g. aphakic patients, or patients with reduced sensitivity to light due to disease of the back of the eye).

Treatment and study plan

Acquisition of images/videos of the bilateral fundus with the holographic doppler laser

Device

Acquisition of images/videos of the bilateral fundus with the holographic Doppler laser

Primary outcomes

  1. Describe the usability of acquisitions (images/videos) of retinal and choroidal vascularization with holographic laser Doppler.

    Time frame: Day0

    Acquisitions (images/videos) will be considered usable if they allow :

    • (1) The ophthalmologist can visually distinguish arterial and venous vascular networks.
    • (2) The device measures arterial and venous blood flow.

Study contacts

Contact information is provided by the study sponsor or research team.

Amélie Yavchitz

CONTACT

[email protected]

33 148036454

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: IREDO

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Oct 16, 2024
Registry last updated
Dec 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.