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OpenTrials
Completed

NCT Number: NCT01639391

Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot Study

Patients with ALS will be included in the reference center for ALS in hospital La Pitié Salpêtrière, Paris.

The study proposes to investigate the pathophysiology of ALS by setting up a fibroblast bank for studying molecular, cellular and genetic parameters of the pathology.

iPS (induced pluripotent stem cells) and then differentiated cells will be generated.

The pathophysiology of ALS will be studied on the 3 types of cells (fibroblasts, iPS, differentiated cells).

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Key information

Conditions

Amyotrophic Lateral Sclerosis Central Nervous System Diseases Metabolic Diseases Motor Neuron Disease Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases Nutritional and Metabolic Diseases Proteostasis Deficiencies Spinal Cord Diseases TDP-43 Proteinopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre référent maladies rares SLA

Paris, 75013, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients over 18 years old
  • ALS sporadic or familial or unknown

Exclusion criteria

  • known cutaneous disease not allowing the biopsy
  • platelets less than 10 000/m3
  • suspected or known xylocain allergy

Treatment and study plan

skin biopsy

Procedure

biopsy 5mm maximum on healthy skin under local anaesthesia.

Primary outcomes

  1. Success of fibroblast culture, amplification, and freezing pellets

    Time frame: 2 months

Secondary outcomes

  1. Induced pluripotent Stem Cells generation success

    Time frame: 2 years

  2. neurones, motoneurones, glial cells obtention from fibroblasts or iPS

    Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Institut Pasteur

Industry

Registry information

Acronym: ALSCELL

Important dates

Study start
2012
Primary completion
2015
Study completion
2015
First posted
Jul 12, 2012
Registry last updated
May 1, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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