Skip to main content
OpenTrials
Completed

NCT Number: NCT03352128

Creatine Supplementation and Cognitive and Physical Tests

To assess whether brain creatine availability has an effect on cognition. To do so we will seek to increase brain creatine concentration via a creatine supplementation protocol.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy Creatine Supplementation

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Human Physiology and Sports Physiotherapy Research Group

Brussels, Belgium

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy (No neurological illness including cardiovascular, renal, and endocrine disorder)
  • Male/female
  • No medication / supplements
  • Non-smoker
  • Low to moderately active
  • Between 18 and 35 years old

Exclusion criteria

  • Injuries
  • Illness
  • Use of medication
  • Use of creatine in the last 3 months
  • History of head trauma or seizure
  • Vegetarian diet [24]
  • Not being able to follow up the restrictions and prohibitions for the subjects (see Restrictions and prohibitions for the subjects)

Treatment and study plan

Creatine

Dietary Supplement

Participants will have to supplement themselves with creatine for 7 days (20g/day).

Calcium lactate

Dietary Supplement

Participants will have to supplement themselves with calcium lactate for 7 days (elemental calcium: 0.780g/day).

Primary outcomes

  1. Cognitive performance - change in accuracy (%) during a 90-min cognitive task (i.e. Stroop task)

    Time frame: During both lab visits (i.e. after both 7-day supplementation protocols); Accuracy (%) will be assessed during both lab visits with a 90-min cognitive task; Accuracy during the 90-min task will be reported as mean accuracy during 8 blocks of 11min15sec

    Accuracy (in %) will be assessed during a cognitive task, this cognitive task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine)

  2. Cognitive performance - change in reaction time (milliseconds) during a 90-min cognitive task (i.e. Stroop task)

    Time frame: During both lab visits (i.e. after both 7-day supplementation protocols); Reaction time (RT) will be assessed during both lab visits with a 90-min cognitive task; RT during the 90-min task will be reported as mean RT during 8 blocks of 11min15sec

    Reaction time (in milliseconds) will be assessed during a cognitive task, this cognitive task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine)

Secondary outcomes

  1. Physical performance - reaction time (milliseconds) during a 7-min visuomotor reaction time task

    Time frame: During both lab visits (i.e. after both 7-day supplementation protocols); visuomotor reaction time will be assessed during both lab visits with a 7-min visuomotor reaction time task.

    Reaction time (in milliseconds) will be assessed during a visuomotor reaction time task, this physical task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine)

Sponsors and collaborators

Lead sponsor

Vrije Universiteit Brussel

Other

Registry information

Official study title

The Effect of Creatine Supplementation on Cognitive and Physical Tests

Acronym: CREA

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Nov 24, 2017
Registry last updated
Oct 8, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.