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OpenTrials
Completed

NCT Number: NCT06202469

Creatine and Ubiquinol for Sperm Quality

This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men. It aims to determine potential enhancements in sperm health to provide insights into male fertility and reproductive health improvement strategies.

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Key information

Conditions

Oligospermia Genital Diseases Genital Diseases, Male Infertility Infertility, Male Male Urogenital Diseases Sperm Count, Low Urogenital Diseases

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

FSPE Applied Bioenergetics Lab

Novi Sad, Vojvodina, 21000, Serbia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 - 35 years
  • Sperm quality test available (at least half will have low sperm quality)
  • Informed consent
  • Healthy BMI (18.5 - 24.9 kg/m2)

Exclusion criteria

  • Major chronic disease and acute injuries
  • History of dietary supplement use during the past 28 days
  • No consent to randomization
  • Participation in other studies

Treatment and study plan

Supplement 1

Dietary Supplement

Creatine monohydrate (5 g/day)

Supplement 2

Dietary Supplement

Creatine monohydrate (5 g/day) plus ubiquinol (200 mg/day)

Placebo

Dietary Supplement

Placebo (inulin)

Primary outcomes

  1. Sperm concentration

    Time frame: Change from baseline sperm concentration at 8 weeks

    Number of sperm per milliliter of semen

Secondary outcomes

  1. Total antioxidant capacity

    Time frame: Change from baseline total antioxidant capacity at 8 weeks

    Level of total antioxidant capacity in semen

  2. Creatine kinase

    Time frame: Change from baseline creatine kinase at 8 weeks

    Level of creatine kinase in semen

  3. Creatine

    Time frame: Change from baseline creatine at 8 weeks

    Level of creatine in semen

  4. The World Health Organisation-Five Well-Being Index (WHO-5)

    Time frame: Change from baseline WHO-5 at 8 weeks

    The World Health Organisation-Five Well-Being Index (WHO-5) is a short self-reported measure of current mental wellbeing.The raw scores are transformed to a score from 0 to 100, with lower scores indicating worse well-being.

Sponsors and collaborators

Lead sponsor

University of Novi Sad, Faculty of Sport and Physical Education

Other

Registry information

Official study title

The Effects of 8-week Creatine Supplementation With and Without Ubiquinol on Sperm Quality Biomarkers in Normospermic and Oligospermic Men

Acronym: CRESPAQ10

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jan 11, 2024
Registry last updated
Dec 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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