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Completed

NCT Number: NCT06371651

Creatine and GAA for Brain Oxygenation

The main aim of this randomized controlled trial is to evaluate cerebral blood oxygenation after 7-day administration of a creatine-guanidinoacetic acid (GAA) mixture in healthy adults before, during, and after a series of cognitive tests.

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Key information

Conditions

Oxygen Deficiency Hypoxia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Applied Bioenergetics Lab at Faculty of Sport and PE

Novi Sad, Vojvodina, 21000, Serbia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-30 years
  • Absence of metabolic disorders or other health complications
  • Provision of signed informed consent

Exclusion criteria

  • History of dietary supplement use within the preceding 4 weeks
  • Lack of consent to randomization
  • Concurrent participation in other studies

Treatment and study plan

Supplement

Dietary Supplement

Dietary supplement containing creatine and guanidinoacetic acid

Placebo

Dietary Supplement

Inert substance

Primary outcomes

  1. Brain oxygen saturation

    Time frame: Change from baseline brain oxygen saturation at 2 weeks

    Percentage of oxygen saturation in prefrontal brain

Secondary outcomes

  1. Hemoglobin index

    Time frame: Change from baseline hemoglobin index at 2 weeks

    Concentration of hemoglobin index in prefrontal brain

Sponsors and collaborators

Lead sponsor

University of Novi Sad, Faculty of Sport and Physical Education

Other

Registry information

Official study title

Enhancing Brain Oxygenation: Effects of Short-Term Co-Administration of Creatine and Guanidinoacetic Acid at Rest and During Stress

Acronym: CREGAA-OXY

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Apr 17, 2024
Registry last updated
May 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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