Skip to main content
OpenTrials
Completed

NCT Number: NCT07067086

Cream Short-term Efficacy Clinical Study

This study aimed to evaluate the short-term efficacy of a facial cream (Formula# 899675 44A) on improving various skin quality and wrinkle parameters after a single application. A total of 44 healthy Chinese women aged 20 to 50 years, with all skin types including 50% sensitive skin, were enrolled. Participants applied the cream once to the full face and neck under supervision, and outcomes were assessed at baseline (T0), 10 hours (T10h), and 24 hours (T24h) post-application. Clinical evaluations and photo-based imaging were used to assess skin plumpness, smoothness, radiance, and multiple types of wrinkles. At the end of the study, 42 participants completed the protocol.

Completed

Looking for future studies?

Notify Me

Key information

Age range

20 year–50 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072

Shanghai, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 1.Chinese female with 20-50 years old (Must have 20-30 years old). 2.In general, good health at the time of the study. 3.All skin types, with 50% sensitive skin. 4.Regular users for cleanser, anti-aging cream and sunscreen product. 5.Self-declare with plumpness, smoothness and wrinkles problems. 6.Clinical grading by dermatologist in terms of: Underneath eye wrinkles: 2≤grade≤4; Forehead wrinkles: 1 <grade≤ 4; Crow's feet wrinkles: grade > 1; Skin smoothness: 3≤ grade≤ 6 (0-9 scale); Skin plumpness: 3≤ grade≤ 6 (0-9 scale); 7.Did not participate any clinical test or cosmetic product test on skin within 3 months.

8.Did not participate any chemical/beauty procedures for previous 6 months. 9.No disagreement of dermatologist because of other reasons that exclude the participation of the subject.

10.Were willing and able to participate as evidenced by signing of informed consent and photo release form.

11.Must be willing to comply with all study protocol requirements.

Exclusion criteria

  • 1.Pregnant or breast-feeding woman or woman planning pregnancy during the study.

2.Subject deprived of rights by a court or administrative order. 3.Major subject to a guardianship order. 4.Subject residing in a health or social care establishment. 5.Patient in an emergency setting. 6.Subject with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema).

7.Subject presenting a stable or progressive serious disease (per investigator's assessment).

8.Immuno-compromised subject. 9.Subject with history of allergy to cosmetic or personal care products or ingredients.

10.Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).

11.Subjects regularly practicing aquatic or nautical sports. 12.Subjects regularly attending a sauna. 13.Subject with physical highly sensitive constitution. 14.Subject with cardiovascular or circulatory history. 15.Subject with a history of skin cancer or malignant melanoma. 16.Intake of antihistamines, antibiotics, corticosteroids, non-steroidal anti-inflammatories or immune-suppressants in the last 6 months before study.

Treatment and study plan

Test Cream

Other

A facial cream (Formula# 899675 44A, 30 mL) was applied once by participants under supervision. 1g of cream was spread over the entire face and neck, followed by targeted massage on wrinkle-prone areas including forehead, crow's feet, underneath eyes, nasolabial folds, and neck folds. Clinical and photo-based evaluations were conducted at baseline (T0), 10 hours (T10h), and 24 hours (T24h) after application.

Primary outcomes

  1. Time effect of cheek plumpness (Visual)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  2. Time effect of skin smoothness (Visual)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  3. Time effect of skin radiance (Visual)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  4. Time effect of skin elasticity (Tactile)

    Time frame: Compare to baseline, 10h, 24h

Secondary outcomes

  1. Time effect of global fine lines (Visual)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  2. Time effect of forehead wrinkles (Photo analysis)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  3. Time effect of crow's feet wrinkles (Photo analysis)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  4. Time effect of skin firmness (Visual)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  5. Time effect of nasolabial folds (Photo analysis)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  6. Time effect of skin hydration (Corneometer)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  7. Time effect of skin TEWL (Tewameter)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  8. Time effect of skin glossiness (Glossymeter)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  9. Time effect of skin redness (Chromameter)

    Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

Sponsors and collaborators

Lead sponsor

ChinaNorm

Industry

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jul 16, 2025
Registry last updated
Jul 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.