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Completed

NCT Number: NCT00638170

Cranberry Juice in the Prevention of Urinary Tract Infections in Children

The objective of the study is to determine whether recurrences of urinary tract infection in children can be prevented with cranberry juice.

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Key information

Conditions

Urinary Tract Infections Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Infections Male Urogenital Diseases Urogenital Diseases Urologic Diseases

Age range

1 year–16 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Oulu

Oulu, 90140, Finland

About this study

Five percent of children have at least one UTI episode and 30% of these episodes recur. Recurrences and the risk of renal damage are indications for long term antimicrobial prophylaxis, but emerging antimicrobial resistance underlines the need for alternatives. The bacteria causing urinary tract infection arise from the stools. Dietary changes can alter the balance of faecal bacteria. Vaccinium berries and products containing lactobacilli have been shown to act against the coliform bacteria that cause most urinary tract infections. In our previous study cranberry juice was effective in preventing symptomatic recurrences of urinary tract infections in women. The objective of our study is to determine whether recurrences of urinary tract infection in children can be prevented with cranberry juice.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Urinary Tract Infection 0-2 months priorly

Exclusion criteria

  • Antibiotic Prophylaxis

Treatment and study plan

Cranberry juice

Biological

5 ml/kg up to 300 ml, 1-2 doses daily for six months

Placebo juice

Biological

5 ml/kg up to 300 ml, 1-2 doses daily for six months

Primary outcomes

  1. Occurrence of the first recurrence

    Time frame: 12 months

Secondary outcomes

  1. Total number of UTI episodes and use of antimicrobials

    Time frame: 12 months

Sponsors and collaborators

Lead sponsor

University of Oulu

Other

Collaborators

  • Ocean Spray, Inc.

Registry information

Official study title

The Efficacy of Cranberry Juice in the Prevention of Urinary Tract Infections in Children - Randomized, Placebo Controlled Multi-Center Study

Important dates

Study start
2001
Primary completion
2009
Study completion
2009
First posted
Mar 18, 2008
Registry last updated
Feb 16, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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