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Completed

NCT Number: NCT00093054

Cranberry Juice for Treatment of Urinary Tract Infections

The purpose of this study is to determine whether daily consumption of cranberry juice lessens the symptoms and prevents the recurrence of urinary tract infections (UTIs). This study will also determine whether drinking cranberry juice for 6 months selects for less virulent bacteria in the rectal, vaginal, and urethral areas.

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Key information

Conditions

Urinary Tract Infections Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Infections Male Urogenital Diseases Urogenital Diseases Urologic Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

University of Michigan

Ann Arbor, Michigan, 48109, United States

About this study

Participants in this study will be randomly assigned to consume either 8 ounces of cranberry juice or placebo juice twice a day for 6 months. Participants will have follow-up visits at 3 and 6 months, and whenever they experience a symptomatic episode. Urine, vaginal and rectal specimens will be taken at each visit to test for the presence of bacteria that cause urinary tract infections. Participants will complete a questionnaire at study entry, Day 3, Weeks 1 and 2, and monthly thereafter or whenever there is a recurrence of symptoms.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Culture-confirmed urinary tract infection at study start

Exclusion criteria

  • Other chronic disease
  • Antibiotics within 48 hours prior to study start
  • Hospitalization for any reason within 2 weeks prior to study start
  • Stones in urinary tract
  • Plans to leave Ann Arbor within 6 months after study start
  • Allergy to cranberry or cranberry compounds
  • Pregnancy

Treatment and study plan

Cranberry juice

Drug

TID dosage for UTI treatment

Placebo cranberry juice

Dietary Supplement

TID placebo dosage to match active comparator

Primary outcomes

  1. Culture

    Time frame: per visit

Sponsors and collaborators

Lead sponsor

National Center for Complementary and Integrative Health (NCCIH)

Nih

Registry information

Official study title

Cranberry Juice and Urinary Tract Infections

Important dates

Study start
2004
Primary completion
2008
Study completion
2009
First posted
Oct 1, 2004
Registry last updated
May 5, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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