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NCT Number: NCT07072975

CPOD Patient's Tolerance of Intermittent Exercise With Inter-exercise Recovery Under Normoxic Hypoxia

Exercise retraining improves the prognosis and quality of life of patients with chronic lung or circulatory diseases. However, exercise intolerance may be caused by excessive ventilatory. Exposure to oxygen-replete air reduces this ventilatory overload, improves sleep and enhances responses to exercise. This study examine the impact of the acute manipulation of oxygen availability during inter-exercise recovery period of an intermittent cycling exercise on perceptual responses.

this randomized, controlled, study include adult patient with COPD. On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed.

Hypoxic exposure during inter-repetition recovery phases would reduce the ventilatory load during exercise. What's more, patients would not be forced to perform the sporting gesture in a restricted space or wearing a mask, limiting dyspnea and the perceived difficulty of the effort. Lastly, the induction of hypoxic stress during the re-training session helped to improve patients' sleep.

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Key information

Age range

40 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHRU Amiens

Amiens, 80480, France

Location contact

Emeric Thiesset, MD

CONTACT

[email protected]

33+3 22 08 80 51

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • from 40 to 60 years
  • follow-up in the pneumology unit of CHU Amiens - Picardie
  • Chronic Obstructive Pulmonary Disease stade II
  • Body mass index from 20 to 30 kg.m-2
  • Tiffeneau index < 70% of predicted value
  • FEV1 from 50 to 80% of predicted values
  • Smoking cessation since at least 1 week
  • Sedentary or physical active
  • Affiliate to social security
  • Written consent

Exclusion criteria

-

Treatment and study plan

Normobaric Hypoxia

Other

Normobaric hypoxia (inspired oxygen fraction of 12.9%) applied between-sets recovery periods

normoxic condition

Other

Between-sets recovery periods under normoxic condition

Primary outcomes

  1. Perception Exertion score with CR10

    Time frame: day 1

    The modified Borg CR10 RPE scale measures exertion on a scale of 0 (no exertion or resting) to 10 (pushing yourself to the max).

Secondary outcomes

  1. Cardiorespiratory responses to exercise

    Time frame: day 1

    Cardiorespiratory responses to exercise is measured with gaseous exchange volumes

Study contacts

Contact information is provided by the study sponsor or research team.

Emeric Thiesset, MD

CONTACT

[email protected]

33+322088051

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: HypoChronoPerf

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jul 18, 2025
Registry last updated
Oct 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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