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OpenTrials
Completed

NCT Number: NCT04616976

COVID-19 With Convalescent Plasma

To clarify the effects of convalescent plasma therapy on SARS-CoV-2 negative conversion rate during hospital stay and 28-day mortality of severe and life-threatening COVID-19 patients.

Completed

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Key information

Conditions

COVID-19 Convalescent Plasma Treatment COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Zhongda Hospital, Southeast University

Nanjing, Jiangsu, 210009, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • > 18 years of age;
  • laboratory-confirmed diagnosis of COVID-19;
  • respiratory failure requiring advanced respiratory support (i.e. high flow nasal cannula[HFNC], noninvasive mechanical ventilation [NIV], and invasive mechanical ventilation [IMV]).

Exclusion criteria

  • no

Treatment and study plan

Convalescent Plasma

Biological

convalescent plasma was get from the patients who recovery from COVID-19

Primary outcomes

  1. 28-day mortality

    Time frame: 28 days

    the mortality from ICU admission to 28 days after admission

Secondary outcomes

  1. SARS-CoV-2 negative conversion rate

    Time frame: up to 60 days

    SARS-CoV-2 viral shedding

Sponsors and collaborators

Lead sponsor

Southeast University, China

Other

Registry information

Official study title

Efficiency of Convalescent Plasma Therapy in Management of Critically Ill Patients With COVID-19: a Matched Case-control Study

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Nov 5, 2020
Registry last updated
Nov 5, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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