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Active, Not Recruiting

NCT Number: NCT06482281

COVID-19 and Childhood Cancer

The investigators will first examine the impact of the COVID-19 pandemic on childhood cancer patients in Sweden and Denmark, both regarding susceptibility to severe COVID-19 among long-term childhood cancer survivors, and, for those diagnosed with childhood cancer during the pandemic, whether the path through primary care to cancer diagnosis as well as short-term survival has changed. Second, the investigators will study childhood cancer incidence before, during and after the pandemic with the particular aim to test the hypothesis regarding an infectious disease etiology for acute lymphoblastic leukemia.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

COVID-19 Childhood Cancer Childhood Leukemia, Acute Lymphoblastic Coronaviridae Infections Coronavirus Infections Hematologic Diseases Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Infections Leukemia Leukemia, Lymphoid Lung Diseases Lymphatic Diseases Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type Nidovirales Infections Pneumonia Pneumonia, Viral Precursor Cell Lymphoblastic Leukemia-Lymphoma RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

0 year–19 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Karolinska Institutet

Stockholm, 17177, Sweden

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for studying severe COVID-19 among childhood cancer survivors:

  • Childhood cancer cases (age 0-19) diagnosed from 1971 in Sweden and Denmark who were alive five years after diagnosis
  • Two different comparisons groups: five age- and sex-matched comparisons for each childhood cancer survivor as well as all siblings of the childhood cancer survivors.
  • All childhood cancer survivors, matched comparisons, and siblings of the survivors should be 20+ at the start of 2020.

Inclusion criteria

for studying childhood cancer incidence and survival and number of contacts with healthcare before the childhood cancer diagnosis:

  • All children (age 0-19) diagnosed with cancer from 2015 in Sweden and Denmark

Exclusion criteria

  • No exclusion criteria

Treatment and study plan

Primary outcomes

  1. Severe COVID-19

    Time frame: Up to 3 years

    Defined as:

    • death with COVID-19 listed as a cause of death
    • hospitalization, or admission to intensive care unit, because of COVID-19 (main diagnosis) or respiratory problems (main diagnosis) AND COVID-19 as secondary diagnosis

  2. Childhood cancer survival

    Time frame: After three and twelve months after the cancer diagnosis and three years after cancer diagnosis

    Overall survival after a childhood cancer diagnosis

  3. Number of contacts before childhood cancer diagnosis

    Time frame: One year before cancer diagnosis

    Number of healthcare contacts (including primary care) the year before the cancer diagnosis

  4. Childhood cancer incidence

    Time frame: From 2015

    Age standardized incidence rates for childhood cancer and cancer subtypes (particularly acute lymphoblastic leukemia) in Sweden and Denmark during and after the pandemic and compare it to the 5 years preceding the pandemic

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Collaborators

  • The Swedish Childhood Cancer Fund
  • The Swedish Research Council

Registry information

Official study title

COVID-19 and Childhood Cancer - Diagnostic Delay, Survival, and COVID-19 Susceptibility

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Jul 1, 2024
Registry last updated
Jul 3, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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