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NCT Number: NCT04737239

Corticosteroid Injection Effectiveness in Carpel Tunnel Patients With Negative or Mild EMG Studies

Carpal Tunnel Syndrome (CTS) is the most common nerve entrapment syndrome worldwide. There are currently no studies examining the effectiveness of corticosteroid injections in patients with normal (negative) EMG studies. The purpose of this study is to gain a better understanding of the duration of symptom improvement post corticosteroid injection in patients with negative or mild EMG studies. The Boston Carpal Tunnel Questionnaire will be given to patients undergoing corticosteroid injections for the treatment of carpal tunnel syndrome to assess their response to the injection. Investigators will collect data retrospectively. The Boston Carpal Tunnel Questionnaire (BCTQ) is administered as per standard protocol to all patients with CTS who have a negative or mild EMG study. The BCTQ assesses the patient's self-reported symptom severity and functional status. Investigators will analyze this data with respect to demographics as well as numbness in the median n. distribution, nocturnal numbness, weakness/atrophy of the thenar musculature, Tinel's sign, Phalen's test, loss of 2-point discrimination, Quick-Dash score, and grip strength score.

The primary outcome will be the Boston Carpal Tunnel Questionnaire outcome score under the different EMG conditions.The secondary outcomes will be numbness in the median n. distribution, nocturnal numbness, weakness/atrophy of the thenar musculature, Tinel's sign, Phalen's test, loss of 2-point discrimination, QuickDash score, and grip strength score. Both outcomes will be examined in patients with negative or mild EMG readings. This information will allow orthopedic physicians to gain a better understanding of the duration of symptom improvement post-corticosteroid injection, allowing them to fine tune their treatment plans for CTS patients.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Henry Ford Health System

Detroit, Michigan, 48202, United States

Location status: Recruiting

Location contact

Charles S Day, M.D., M.B.A.

CONTACT

[email protected]

313-916-5846

Charles S Day, MD, MBA

PRINCIPAL_INVESTIGATOR

Elizabeth A Washnock-Schmid, B.S.

CONTACT

[email protected]

8103474714

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who speak English
  • Patients who are 18 years or older
  • Patients who are clinically diagnosed with CTS
  • Patients who have a negative or mild EMG study
  • Patients who receive a corticosteroid injection after obtaining a negative or mild EMG study

Exclusion criteria

  • Patients who do not speak English
  • Patients who are younger than 18 years of age
  • Patients who have experienced previous trauma to the wrist
  • Patients who have had previous treatment for CTS including but not limited to corticosteroid injection or surgery
  • Patients with a moderate or severe EMG study

Treatment and study plan

Corticosteroid injections for CTS treatment

Other

Treatment of carpel tunnel syndrome with corticosteroid injections for EMG mild and EMG negative patients

Primary outcomes

  1. Boston Carpel Tunnel Questionnaire

    Time frame: Dec 23 2020-Dec 22 2021

    Scaled 1-5, higher scores indicate worse outcomes

Secondary outcomes

  1. Number of patients with numbness in the median n. distribution

    Time frame: Dec 23 2020-Dec 22 2021

    Positive test includes numbness in parts of palm, thumb, second and third finger, assessed by physician

  2. Number of patients with weakness/atrophy of the thenar musculature

    Time frame: Dec 23 2020-Dec 22 2021

    Positive test includes weakness in grip or holding objects as described by participant, assessed by physician

  3. Number of patients with positive Tinel's Sign

    Time frame: Dec 23 2020-Dec 22 2021

    Positive sign includes 'pins and needles' in parts of palm, thumb, second and third finger upon percussion of median nerve, assessed by physician

  4. Number of patients with positive Phalen's Test

    Time frame: Dec 23 2020-Dec 22 2021

    Positive test includes pain in parts of palm, thumb, second and third finger associated with compression of the median nerve, assessed by physician

  5. 2-point discrimination Test

    Time frame: Dec 23 2020-Dec 22 2021

    Scaled 2-8mm, higher scores indicate worse outcomes

  6. QuickDash score

    Time frame: Dec 23 2020-Dec 22 2021

    Scaled 1-100, higher scores indicate worse outcomes

  7. Grip Strength score

    Time frame: Dec 23 2020-Dec 22 2021

    Scored in pounds(lbs), higher scores indicate better outcomes

Study contacts

Contact information is provided by the study sponsor or research team.

Aaron R Prater, M.S.

CONTACT

[email protected]

2692752828

Elizabeth A Washnock-Schmid, B.S.

CONTACT

[email protected]

8103474715

Sponsors and collaborators

Lead sponsor

Henry Ford Health System

Other

Registry information

Official study title

Corticosteroid Injection Effectiveness in Carpel Tunnel Patients With Negative or Mild EMG

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
Feb 3, 2021
Registry last updated
Mar 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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