Skip to main content
OpenTrials
Completed

NCT Number: NCT02596789

Cortical Excitability Using Transcranial Magnetic Stimulation and Neuronavigation Device

This study has two main goals :

* to investigate the impact of aging on cortical excitability (CE) * to investigate the impact of "state dependency" on CE, using a cognitive task and an emotional one.

A Neuronavigation system of transcranial magnetic stimulation is used, and electromyographic response are recorded.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy Volunteers

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Psychiatry & Neurology - University Hospital Grenoble

Grenoble, 38000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male or female
  • age 18-75
  • signed informed consent
  • normal physical examination

Exclusion criteria

  • less 18 or more 75 years of age
  • contra indication to TMS: epilepsia or seizures, metallic head devices, cardiac pacemaker, pregnancy, jet lag or severe insomnia the night before
  • severe physical disease
  • treatment with psychotropic drugs
  • overt psychiatric disease
  • alcohol consumption before the examination

Treatment and study plan

TMS "Magpro®, Magventure Inc" device

Device

Primary outcomes

  1. Amplitudes of Motor evoked Potentials (µV) for ICI and ICF.

    Time frame: Participants will be followed for an expected average of one month

    Motor Evoked Potential (MEP) from the first dorsal interosseous are register during the stimulations.

    Intracortical Inhibition (ICI) and Facilitation (ICF) are a paired-pulse TMS measure of cortical excitability. A short Interval interstimuli (2ms) leads to a cortical inhibition, which reflects the GABAergic neurotransmission; whereas a longer interval interstimuli leads to a cortical facilitation, which reflects glutamatergic neurotransmission.

  2. Durations of Cortical Silent Period (ms)

    Time frame: Participants will be followed for an expected average of one month

    Cortical Silent Period (CSP) is a single-pulse TMS measure of cortical inhibition, stimulations are applied while subjects are exerting a muscular contraction of the thum-index pinch and lead to a muscular cancellation. Duration of this silence is measured.

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Registry information

Official study title

Study of Cortical Excitability in Healthy Subjects With Transcranial Magnetic Stimulation (TMS) and a Neuronavigation Device

Acronym: RC-TMS

Important dates

Study start
2012
Primary completion
2016
Study completion
2016
First posted
Nov 4, 2015
Registry last updated
May 8, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.