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NCT Number: NCT04286308

Cortical-Basal Ganglia Speech Networks

In this research study the researchers want to learn more about brain activity related to speech perception and production.

Recruiting

Interested in participating?

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Dyskinesias Dystonia Essential Tremor Movement Disorders Nervous System Diseases Neurodegenerative Diseases Neurologic Manifestations Parkinsonian Disorders Pathological Conditions, Signs and Symptoms Signs and Symptoms Synucleinopathies

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Speech production is disrupted in a number of neurological diseases that involve the basal ganglia, including Parkinson's disease (PD) and dystonia. The investigators will use a novel experimental approach and combination of analytic techniques to elucidate the contribution of neural activity in cortical-basal ganglia circuits to the hierarchical control of speech production, in subjects undergoing deep brain stimulation surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects scheduled for DBS implantation, as determined by the clinical multidisciplinary movement disorders board with definitive diagnosis of Parkinson's disease, essential tremor or dystonia.
  • Subjects able to provide informed consent and comply with task instructions.
  • Subjects 18-85 years old

Exclusion criteria

  • Subjects with reported hearing loss.
  • Non-English-speaking subjects

Treatment and study plan

electrophysiological data collection

Other

Electrophysiological data collection at the time of DBS surgery.

Primary outcomes

  1. The number of subjects providing the interpretable speech related electrophysiological data collection.

    Time frame: Duration of single DBS surgery

    The number of subjects providing the interpretable speech related electrophysiological data during DBS surgery.

Study contacts

Contact information is provided by the study sponsor or research team.

Erin Donahue, PhD

CONTACT

[email protected]

Mark Richardson, MD, PhD

CONTACT

[email protected]

617-726-8849

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Registry information

Important dates

Study start
2020
Primary completion
2027
Study completion
2027
First posted
Feb 27, 2020
Registry last updated
Mar 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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