Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients

This study aims to address the challenges of enteral nutrition support in critically ill ICU patients with varying gastrointestinal function. We'll use bedside Doppler ultrasound to monitor superior mesenteric artery (SMA) blood flow changes post - feeding, exploring its correlation with Acute Gastrointestinal Injury (AGI) and other hemodynamic indicators. Our goals are to identify the patterns of SMA blood flow changes, establish a predictive model linking SMA blood flow reactivity to AGI risk, and propose individualized enteral nutrition strategies based on intestinal hemodynamics. Through this innovative approach, we hope to enhance the safety of enteral nutrition, reduce AGI incidence, and improve patient outcomes.

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Key information

Conditions

Intestinal Ischemia Critical Illness Disease Attributes Enteral Nutrition Feeding Hemodynamics Pathologic Processes Pathological Conditions, Signs and Symptoms Ultrasonography, Doppler

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Peking union medical college hospital

Beijing, Beijing Municipality, 100730, China

Location status: Recruiting

Location contact

Yuankai Zhou Attending Physician, MD

CONTACT

[email protected]

00886-10-69152300

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults aged ≥18 years and ≤80 years.
Admitted to the study with a expected stay of more than 72 hours.
Require initiation of enteral nutrition support.

Exclusion criteria

Pre-existing severe gastrointestinal diseases.
Patients with gastrointestinal bleeding.
Patients with bowel obstruction.
Pregnant or lactating women.
Patients with contraindications to bedside Doppler ultrasound.

Treatment and study plan

Enteral nutrition

Other

We'll use an enteral nutrition intervention with intact protein formulations. Initiate nasogastric tube feeding at 20ml/h and continue for 24 hours. Adjust feeding strategies based on patients' SMA blood flow reactivity.

Primary outcomes

feeding intolerance

Time frame: From enrollment to the end of treatment at 3 days

the incidence of feeding intolerance, defined as the frequency of feeding interruptions or reductions due to gastrointestinal complications like vomiting, gastric residuals, or abdominal distension during the study period.

Sponsors and collaborators

Lead sponsor

Peking Union Medical College Hospital

Other

Registry information

Official study title

Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Functional Injury in Critically Ill Patients

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jun 3, 2025
Registry last updated: Sep 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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