Skip to main content
OpenTrials
Completed

NCT Number: NCT03724825

Correlation of Serum Adropin to Testosterone and Adiponectin in Obese Men

Obesity is associated with low testosterone in men and with dyslipidemia. Adropin hormone is negatively correlated with body mass index and is associated with dyslipidemia.

correlation between adropin and testosterone will be evaluated.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Obesity Body Weight Dyslipidemias Lipid Metabolism Disorders Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–50 year

Sex eligibility

Male

Study type

Observational

Primary location

Aswan University Hospital

Aswān, 81528, Egypt

About this study

Obesity, a worldwide epidemic is associated with multiple adverse health outcome as diabetes mellitus, hypertension and cardiovascular diseases caused mainly by dyslipidemia linked to obesity. Low testosterone levels in obese men were found associated with dyslipidemia.

Adropin is a new metabolic hormone that was first isolated in liver and brain tissues, It was observed that mice fed on a high-fat diet (HFD) had a rapid increase in adropin expression compared to control values. In human also, adropin levels were negatively correlated with body mass index (BMI) and were associated with dyslipidemia.

Adiponectin is a protein that is mainly produced by white adipose tissue and has an important role in lipid metabolism. Serum adiponectin concentrations were decreased in obese compared to normal weight men and significantly correlated with testosterone level.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age from 18 years to 50 years. Clinically free except from obesity

Exclusion criteria

  • Diabetes mellitus Hypertension Heart failure Kidney disease Smoking

Treatment and study plan

lipid profile: Total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL))

Diagnostic Test

blood samples will be collected after 10 hours fasting

Total testosterone

Diagnostic Test

blood samples will be collected after 10 hours fasting

Adropin

Diagnostic Test

blood samples will be collected after 10 hours fasting

Adiponectin

Diagnostic Test

blood samples will be collected after 10 hours fasting

Primary outcomes

  1. changes in lipid profile (TC, TG, LDL, HDL) levels

    Time frame: 6 months

    expected higher TC, TG, LDl levels and lower HDL levels in obese men compared to normal

  2. changes in total testosterone levels

    Time frame: 6 months

    expected lower testosterone levels in obese men compared to normal men

  3. changes in adropin level

    Time frame: 6 months

    expected lower adropin levels in obese men compared to normal men

  4. changed in adiponectin levels

    Time frame: 6 months

    expected lower adiponectin level in obese men compared to normal men

  5. correlation between adropin and testosterone

    Time frame: 6 months

  6. correlation between adropin and adiponectin

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Aswan University Hospital

Other

Registry information

Important dates

Study start
2018
Primary completion
2019
Study completion
2020
First posted
Oct 30, 2018
Registry last updated
Mar 2, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.