Correlation of PaCO2 to the Inspired and Expired Oxygen Gradient

The purpose of this study is to evaluate whether a correlation exists between the partial pressure of carbon dioxide existing within arterial blood and the gradient between inhaled and exhaled fractions of oxygen.

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Key information

Conditions

Neurosurgery

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Swedish Medical Center

Seattle, Washington, 98122, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 18 to 65.
Scheduled for surgical procedure that will last at least 2 hours.
Arterial cannulation is planned because of either the complexity of the surgery or patient comorbidity.
At least two arterial blood gas analyses are planned during the surgery.

Exclusion criteria

No arterial cannulation is necessary or planned for the procedure.

Treatment and study plan

Primary outcomes

Correlate the level of carbon dioxide within arterial blood to inspired and expired oxygen gradient.

Time frame: At least 2 hours

Compare the levels of carbon dioxide found in the patient's blood to the amounts of carbon dioxide and oxygen in the air that the patient inhales and exhales. If a relationship exists between the levels of carbon dioxide in the blood and the levels of carbon dioxide and oxygen inhaled and exhaled by the patient, anesthesiologists will be able to use this relationship to adjust ventilators during anesthesia without having to take blood from an artery.

Sponsors and collaborators

Lead sponsor

Swedish Medical Center

Other

Registry information

Acronym: O2 Fraction

Important dates

Study start: 2011
Primary completion: 2014
Study completion: 2016
First posted: Jan 20, 2012
Registry last updated: Jan 24, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed