Correlation of Albuminuria With Arterial Stiffness

The investigators aim to investigate the relationship between albuminuria and arterial stiffness in diabetic patients, hypertensive patients and healthy subjects.

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Key information

Conditions

Diabetes Mellitus Albuminuria Cardiovascular Diseases Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Glucose Metabolism Disorders Hypertension Male Urogenital Diseases Metabolic Diseases Nutritional and Metabolic Diseases Pathological Conditions, Signs and Symptoms Proteinuria Signs and Symptoms Urination Disorders Urogenital Diseases Urologic Diseases Urological Manifestations Vascular Diseases Vascular Stiffness

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine

Istanbul, 34390, Turkey (Türkiye)

About this study

CONTEXT: Albuminuria is an important cardiovascular risk factor. Arterial stiffness also gives important information about atherosclerosis. Oscillometric methods may be useful in assessing arterial stiffness in a mainly operator independent way.

OBJECTIVE: We aim to investigate the relationship between albuminuria and arterial stiffness measured with an oscillometric device in diabetic patients, hypertensive patients and healthy subjects.

METHODS: 152 diabetic patients, 152 hypertensive patients and 152 healthy subjects are planned to be enrolled in this study. The measurements will be done between 9:00 and 13:00. After the measurements, blood and urine samples will be obtained, centrifugated and kept in -80°C until assayed. Afterwards, echocardiographic left ventricle mass index will be calculated. The correlation between albuminuria and arterial stiffness will be assessed as the primary outcome measure.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diabetes Mellitus
Hypertension
Healthy subjects

Exclusion criteria

Symptomatic cardiovascular diseases (heart failure, history of myocardial infarction, etc.)
Renal failure
Pregnancy
Diseases of the aorta

Treatment and study plan

Primary outcomes

Correlation between albuminuria and arterial stiffness

Time frame: Albuminuria and arterial stiffness will be assessed simultaneously (i.e. in the same morning)

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Official study title

Assessment of the Association Between Albuminuria and Arterial Stiffness in Diabetic Patients, Hypertensive Patients and Healthy Controls

Important dates

Study start: 2009
Primary completion: 2011
Study completion: 2012
First posted: Jan 1, 2010
Registry last updated: Aug 30, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed