Correlation Between Various Inflammatory Markers and Vascular Inflammation Measured by 18FDG-PET

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Various inflammatory markers such as LpPLA2,MCP-2 and hsCRP are well-known prognostic factors for the cardiovascular event.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between various inflammatory markers and vascular inflammation detected by 18FDG-PET.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Vascular Diseases

Age range

20 year–88 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hye Jin Yoo

Seoul, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy patients for visiting routine medical check in our clinic

Exclusion criteria

History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
Diabetes
Stage 2 hypertension (resting blood pressure, ≥160/100 mmHg)
Malignancy
Severe renal or hepatic disease
Subjects taking medications that might affect inflammation such as NSIAD and statin

Treatment and study plan

Cross section study

Other

This is not intervention study. The purpose of the study is to examine the relationship between various inflammatory markers and PET imaging at the cross section setting

Primary outcomes

Correlation between various inflammatory markers including LpPLA2,MCP-1 and hsCRP and vascular inflammation analyzed by 18FDG-PET

Time frame: 12 weeks

Secondary outcomes

Correlation between various inflammatory markers and atherosclerosis measured by carotid intima media thickness

Time frame: 12 weeks

Sponsors and collaborators

Lead sponsor

Korea University

Other

Registry information

Official study title

Correlation of Inflammatory Markers Such as LpPLA2,MCP-1 and hsCRP for Predicting Vascular Inflammation; Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography

Important dates

Study start: 2009
Primary completion: 2010
Study completion: 2010
First posted: Dec 1, 2009
Registry last updated: Feb 22, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed