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NCT Number: NCT07141602

Correlation Between Stages of Mandibular 2nd Molar Calcification and CVMI for Assessment of Skeletal Maturation: A Cross Sectional Study

The aims of this study will be:

1. To investigate the relationships between mandibular second molar calcification stages and skeletal maturity in Egyptian population, and 2. To evaluate whether the mandibular second molar calcification stages can be used as a reliable diagnostic tool to assess skeletal maturity in Egyptian population.

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This study is active but is not currently recruiting participants.

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Key information

Age range

9 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of Dentistry-Cairo University

Cairo, Egypt

About this study

This cross-sectional study will include 106 Egyptian subjects with age range between 9 and 18 years old, who will present to outpatient clinic of Orthodontic department, Faculty of Dentistry, Cairo University, and will be classified according to their gender into two groups (males and females). Radiographs (panorama and cephalogram) will be collected from all study participants who meet inclusion criteria for data analysis. The inclusion criteria will be as follows:

  • Chronological age ranging from 9 to 18 years
  • No serious illness
  • Normal overall growth and development
  • Absence of abnormal dental conditions, such as impaction, transposition, and congenitally missing teeth
  • Absence of previous history of trauma or disease to the face and neck
  • Absence of orthodontic treatment
  • No permanent teeth extracted

We will obtain panoramic and lateral cephalometric radiographs of 106 Egyptian subjects from the pretreatment records of patients attending clinics for orthodontic treatment.

All radiographic assessments will be performed in a darkened room. Any radiograph that shows motion dullness or has poor contrast will be discarded. A single radiologist will expose and develop all radiographs.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Chronological age ranging from 9 to 18 years
  • No serious illness
  • Normal overall growth and development
  • Absence of abnormal dental conditions, such as impaction, transposition, and congenitally missing teeth
  • Absence of previous history of trauma or disease to the face and neck
  • Absence of orthodontic treatment
  • No permanent teeth extracted

Exclusion criteria

-

Treatment and study plan

lateral cephalometric x- ray and dental panoramic tomogram

Diagnostic Test

lateral cephalometric x- ray and dental panoramic tomogram

Primary outcomes

  1. to evaluate the frequency of stage E of dental index in female subjects.

    Time frame: one year

    to evaluate the frequency of stage E of dental index in female subjects.

Secondary outcomes

  1. to evaluate relationships between the stages of calcification of mandibular second molar (DI) and cervical vertebrae maturation index (CVMI).

    Time frame: one year

    to evaluate relationships between the stages of calcification of mandibular second molar (DI) and cervical vertebrae maturation index (CVMI).

Sponsors and collaborators

Lead sponsor

Mohamed Abd El-Ghafour

Other

Registry information

Official study title

Correlation Between Stages of Mandibular Second Molar Calcification and Cervical Vertebrae Maturation Index for Assessment of Skeletal Maturation: A Cross Sectional Study

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Aug 26, 2025
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.