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Completed

NCT Number: NCT06359457

Correlation Between Serum Progesterone Level And Primary Dysmenorrhea

This study will be conducted to determine the correlation between the levels of serum progesterone and Menstrual Symptoms In Young Females with primary dysmenorrhea.

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Key information

Conditions

Primary Dysmenorrhea Dysmenorrhea Menstruation Disturbances Neurologic Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Pelvic Pain Signs and Symptoms

Age range

17 year–25 year

Sex eligibility

Female

Study type

Observational

Primary location

Menna Allah Youssef Nasr El-Dien

Cairo, Egypt

About this study

One hundred adult females with primary dysmenorrhea will participate in this study. They will be recruited from the Gynaecological outpatient clinic, Kasr El Ainy University Hospital, Cairo, Egypt Many studies reported that primary dysmenorrhea was the result of increased prostaglandin, especially prostaglandin F2α (PGF2α) and prostaglandin E2 (PGE2) which produced the effect through the cyclooxygenase pathway, and further led to uterine ischemia hypoxia. Nevertheless the relationship between the serum progesterone level and menstrual symptoms was not completely clear. Hence, this study will investigate the association between the serum progesterone level and menstrual symptoms in young females with primaryf dysmenorrhea.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • One hundreds adult females were suffered from primary dysmenorrhea.
  • Their age was ranged from 17 to 24 years.
  • Their body mass index was ranged from 20 to 25 kg/m2.

Exclusion criteria

  • Any participant will be excluded from the study if they have:
  • Irregulars or infrequent menstrual cycles.
  • Pacemaker, Myasthenia gravis, hyperthyroidism, active tuberculosis and psychosis.
  • Pelvic pathology.

Treatment and study plan

Primary outcomes

  1. Serum progesterone level

    Time frame: 1 month

    Blood samples will be taken by physician for each girl, and will send to laboratory center to measure the progesterone level in the blood. The normal serum progesterone level at 21st day is 4-20 ng

  2. Pain intensity

    Time frame: 1 month

    It will be measured by Visual analogue scale. It is 10 cm line with values ranging from 0 to 10. 0 indicates no pain nd 10 indicates the worst pain.

  3. Physical and psychological menstrual symptoms

    Time frame: 1 month

    It will be measured by menstrual symptoms questionnaire. It is 25 items split into two categories which used to assess the physical and psychological symptoms associated with dysmenorrhea. The score on each item ranged from 1 (never) to 5 (always) with a higher composite score indicating more symptoms

  4. Correlation between serum progesterone level and pain

    Time frame: 1 month

    The correlation between serum progesterone level and pain intensity measured by the VAS will be conducted

  5. Correlation between serum progesterone level and menstrual symptoms

    Time frame: 1 month

    The correlation between serum progesterone level and menstrual symptoms measured by the menstrual symptom questionnaire will be conducted

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Correlation Between Serum Progesterone Level And Menstrual Symptoms In Young Females With Primary Dysmenorrhea

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Apr 11, 2024
Registry last updated
Jan 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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