Correlation Between Quality of Life and Severity of Parkinson's Disease

This study aim to evaluate the correlation between Quality of Life (QoL) and severity of Parkinson's Disease (PD) by assessing the presence of an optimal cut-off point on the Parkinson's disease questionnaire (PDQ-39) as related to the Hoehn & Yahr (H&Y) scale in a cohort of Italian adults with PD.

A multicenter, cross-sectional study was performed in central and northern Italy. This study was conducted on a cohort of consecutive individuals at three neurologic outpatient clinics. All participants were evaluated with the PDQ-39, and the severity of PD was recorded according to the H&Y scale by a neurologist. Receiver operating characteristic (ROC) curves and coordinates of the curve, which were visually inspected, were used to find cut-off points with optimal sensitivity and specificity. These were in turn used to determine the optimal PDQ-39 cut-off score for identifying disease severity according to H&Y stages.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Quality of Life Synucleinopathies

Age range

50 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Human Neurosciences, Sapienza University of Rome

Roma, RM, 00185, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age > 50 but < 90 years,
H&Y stages I, II, III, and IV,
a mini-mental state examination > 22 points,
a minimum level of five years of education.

Exclusion criteria

Individuals with emotional or psychiatric problems (as determined by clinical screening)

Treatment and study plan

No intervention

Other

All participants were evaluated with the PDQ-39, and the severity of PD was recorded according to the H&Y scale by a neurologist.

Primary outcomes

Hoehn & Yahr (H&Y)

Time frame: at admission to the neurologic outpatient clinics

severity of Parkinson's disease
Parkinson's Disease questionnaire (PDQ-39)

Time frame: at admission to the neurologic outpatient clinics

quality of life

Sponsors and collaborators

Lead sponsor

R.O.M.A. - Rehabilitation & Outcome Measures Assessment

Other

Registry information

Official study title

Correlation Between Quality of Life and Severity of Parkinson's Disease by Assessing an Optimal Cut-off Point on the Parkinson's Disease Questionnaire (PDQ-39) as Related to the Hoehn & Yahr (H&Y) Scale

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Oct 1, 2019
Registry last updated: Oct 1, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed