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Completed

NCT Number: NCT05113121

Correlation Between Pupil Size and Ocular Signs of Pseudoexfoliation Syndrome

To study possible correlation between the size of the pupil in both room light and after dilation between both eyes in bilateral pseudoexfoliation with Intraocular pressure, lens clarity and stability, Optic disc , Visual changes and glaucoma changes by optical coherence tomography

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Key information

Conditions

Pseudoexfoliation Syndrome Cataract Exfoliation Syndrome Eye Diseases Glaucoma Iris Diseases Lens Diseases Ocular Hypertension Pseudoexfoliation Glaucoma in Both Eyes Pseudoexfoliation of Lens; Glaucoma Uveal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Assiut University

Asyut, Egypt

About this study

For each patient. Full preoperative ophthalmological assessment will be done using slit lamp , size of the pupil in regular room light (usually around 2000 Lux) and post dilation with tropicamide 1%. baseline IOP measurement using Goldmann applanation tonometer, UCDVA (Uncorrected Distance Visual Acuity)and CDVA (Corrected Distance visual acuity), lens opacification or clarity, stability or subluxation. corneal endothelial cell count. Fundus examination using 90 D or 78D lenses, Humphrey visual field (24-2) analysis and optical coherence tomography on retinal nerve fiber layer (RNFL) and ganglion cell complex.(GCC)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All patients with pseudoexfoliation syndrome

Exclusion criteria

previous ocular surgery or ocular trauma affecting pupil. Any systemic or neurologic disease affecting pupil

Treatment and study plan

, Humphrey visual field (24-2) analysis and optical coherence tomography on retinal nerve fiber layer (RNFL) and ganglion cell complex.(GCC)

Diagnostic Test

, Humphrey visual field (24-2) analysis and optical coherence tomography on retinal nerve fiber layer (RNFL) and ganglion cell complex.(GCC)

Primary outcomes

  1. correlation between pupil size and severity of Pseudoexfoliation

    Time frame: 2-3 months

    in each eye of the same patient we study correlation between pupil size with ntraocular pressure, lens status, corneal endothelial count and glaucomatous damage represented by (optic disc changes (cup to disc ratio) and OCT changes (RNFL and GCC)

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Correlation Between Pupil Size and Ocular Signs in Pseudoexfoliation Syndrome (PEX): a Contralateral Eye Study.

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Nov 9, 2021
Registry last updated
Apr 12, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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