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OpenTrials
Completed

NCT Number: NCT06573710

Correlation Between Postoperative Pain and Apical Extrusion of Different Irrigation Activation Techniques

The aim of this clinical trial is :

To evaluate effect of different techniques of irrigant activation:

1. LASER activation 2. sonic activation 3. ultrasonic activation 4. passive needle irrigation

On:

1. Postoperative pain in vital teeth (Randomized controlled trial) 2. Amount of apical extrusion (In vitro study) Participants will describe their preoperative pain and postoperative pain level at fixed time interval Research will compare postoperative pain accompanied with different irrigant activation techniques and correlate it to amount of debris extrusion

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Key information

Conditions

Pulpitis - Irreversible

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ain Shams University

Cairo, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age group 18-50 years
  • Males and females
  • Lower molars with symptomatic irreversible pulpitis without apical periodontitis

Exclusion criteria

  • Patients with uncontrolled health conditions
  • Immunocompromised patients
  • Teeth with periodontal diseases
  • Teeth with calcified canals
  • pregnant patients

Treatment and study plan

sonic activator

Device

Polyamide EDDY tips 28mm long is inserted in the canal 2mm short of the working length operated at 6,000 Hz. Activation is done for three cycles each for 20sec. The tip is moved vertically in up and down motion, 1ml is used for each activation cycle followed by 2ml 17% EDTA20

LASER activation

Device

Diode laser 980nm is used to activate the irrigant using fiber optic tip of (200micrometer) and power of 1.5w continuous mode. The tip is placed 2 mm shorter than the working length. Laser irradiation is done for each canal for 20 secs repeated over three cycles for total time of 60 secs and 10 secs pauses between each cycle

Ultrasonic activation

Device

ED60tip is used with ultrasonic device operated on mode E and inserted in the canal 2mm short of the working. Activation is done for three cycles each for 20 sec. The tip is moved vertically in up and down motion,1ml is used for each activation cycle followed by 2ml 17% EDTA

passive irrigation with Endodontic needle

Device

Each canal is irrigated with side vented endodontic needle 30G Placed 2mm short of the working length with total time of 60 secs followed by 2ml 17% EDTA

Primary outcomes

  1. Evaluation of postoperative pain

    Time frame: 8,24,48 hours and one week

    Numerical Rating Scale

Secondary outcomes

  1. Frequency of analgesic intake

    Time frame: 8,24,48 hours and one week

    number of tablets

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Correlation Between Postoperative Pain and Apical Extrusion of Different Irrigation Activation Techniques (Randomized Controlled Trial - an In Vitro Study)

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 27, 2024
Registry last updated
Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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