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Completed

NCT Number: NCT03972670

Correlation Between Postoperative Central Corneal Thickness and Endothelial Damage After Cataract Surgery

To study correlation between postoperative corneal edema and endothelial cell loss after cataract surgery by microcoaxial phacoemulsification.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Cataract surgery facilitates improved visual acuity through extraction of an opacified lens, followed by intraocular lens implantation. An average adult cornea has 2000 to 2500 cells/mm2, a count that diminishes with age with a rate of attrition of approximately 0.3% to 0.5% per year. Long-term postoperative corneal transparency depends on the morphological stability and functional integrity of the corneal endothelium. It is well established that all surgical interventions that require entry into the anterior chamber result in some damage to the corneal endothelium.

Endothelial cell loss results in cell hypertrophy to maintain continuity, resulting in a change in endothelium cell density and morphology. Many studies have assessed the impact of various surgical techniques on endothelial damage and numerous studies have investigated the factors influencing endothelial cell loss after phacoemulsification. The goal of this study is to investigate the correlation of postoperative corneal edema with the reduction of endothelial corneal cell density after phacoemulsification.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The presence of senile cataract with equivalent grades and a history of visual acuity regression

Exclusion criteria

  • Patient with total white cataract
  • With history of ocular surgery
  • With other eye diseases (corneal pathology, Fuchs dystrophy, uveitis and glaucoma) or systemic diseases (diabetic disorder and dementia)

Treatment and study plan

Primary outcomes

  1. Pachymetry

    Time frame: Day 1

    Measurement of the thickness of the eye's cornea with a pachymeter

Secondary outcomes

  1. Endothelial cell density

    Time frame: Day 1

    Endothelial cell density measurements with noncontact specular microscope

  2. Pachymetry after 1 month

    Time frame: Day 30

    Measurement of the thickness of the eye's cornea with a pachymeter

  3. Endothelial cell density after 1 month

    Time frame: Day 30

    Endothelial cell density measurements with noncontact specular microscope

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Régional Metz-Thionville

Other

Registry information

Official study title

Correlation Between Postoperative Central Corneal Thickness and Endothelial Damage After Cataract Surgery by Phacoemulsification

Acronym: ECOCHI

Important dates

Study start
2014
Primary completion
2014
Study completion
2018
First posted
Jun 4, 2019
Registry last updated
Jun 4, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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