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OpenTrials
Completed

NCT Number: NCT02869360

Correlation Between PET and Advanced MRI in Multiple Sclerosis

Traditional Magnetic Resonance Imaging (MRI) in Multiple Sclerosis (MS) has enabled clinicians to measure disease activity but there are inherent limitations. Clinical/radiographic dissociation can be seen in some patients and the abnormalities are not specific.

This pilot study is an opportunity to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

MS Clinical Trials Group - UBC

Vancouver, British Columbia, V6T 1Z3, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with Multiple Sclerosis according to the 2011 McDonald criteria.
  • Aged 18 to 60
  • High or mixed affinity binder to rs6971 TSPO polymorphism

Exclusion criteria

  • Pregnant or breastfeeding
  • Suffering from an unstable medical condition
  • Have a neurological or ocular disorder other than MS
  • Any contra-indications to MRI

Treatment and study plan

Primary outcomes

  1. Whole Brain PBR28 binding

    Time frame: Baseline

Secondary outcomes

  1. Lesional PiB binding

    Time frame: Baseline

  2. Myelin Water Imaging

    Time frame: Baseline

  3. MR Spectroscopy (Total NAA, NAA/Cr, mI)

    Time frame: Baseline

  4. Optical Coherence Tomography (RNFL thickness)

    Time frame: Baseline

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Collaborators

  • Teva Pharmaceuticals USA

Registry information

Official study title

Pilot Study of Positron Emission Tomography (PET) Imaging: Correlations With Advanced Magnetic Resonance Imaging in Multiple Sclerosis

Important dates

Study start
2016
Primary completion
2019
Study completion
2019
First posted
Aug 16, 2016
Registry last updated
Oct 3, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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