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NCT Number: NCT04375137

Correlation Between Oxidative Stress Status and COVID-19 Severity

During the new COVID-19 pandemic physicians all over the world have faced different challenges .Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement.

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Key information

Conditions

Oxidative Stress

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Nooshin Dalili

Tehran, Iran

About this study

Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement. Demographic and lab data of 60 COVID-19 confirmed positive cases gathered .These patients divided in to two arms: 1- severe COVID-19 which were intubated or admitted in intensive care unit due to severe hypoxia 2- non-severe COVID-19 patients which were not hypoxic and admitted in ward with no need to invasive oxygenation. All patients had positive RT-PCR positive nasopharyngeal swab results for COVID-19 or Lung CT scan compatible with COVID-19. Malondialdehyde(MDA) , Biopterin, Neopterin, SOD, Glutathione levels would be checked by ELISA tests and compared between these two groups and healthy controls.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • more than 18 years old
  • positive RT-PCR COVID-19
  • compatible lung CT with COVID-19

Exclusion criteria

  • not signing informed consent
  • using antioxidants
  • using statins

Treatment and study plan

Oxidative Stress ELISA Kit

Diagnostic Test

Checking oxidative stress markers and redox system status

Primary outcomes

  1. MDA concentration

    Time frame: 2 weeks

    MDA x 2 ULN in severe COVID

Secondary outcomes

  1. Biopterin concentration

    Time frame: 2 weeks

    Difference between severe and controls

  2. Neopterin rate of increase

    Time frame: 2 weeks

    Difference between severe and controls

Sponsors and collaborators

Lead sponsor

Shahid Beheshti University of Medical Sciences

Other

Registry information

Official study title

Correlation Between Oxidative Stress Markers and COVID-19 Severity Index

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
May 5, 2020
Registry last updated
Jul 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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