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OpenTrials
Completed

NCT Number: NCT01958411

Correlation Between NAFLD, Epicardial Adipose Tissue and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)

* Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques. * Non-alcoholic fatty liver disease (NAFLD) is closely associated with many cardiometabolic risk factors. NAFLD can be detected by measuring liver fat accumulation using computed tomography (CT). * Also epicardial adipose tissue (EAT) volume as determined by computed tomography (CT) is an independent marker of cardiovascular events in the general population. * Therefore, the purpose of this investigators study is to compare the NAFLD severity and EAT volume with FDG uptake measured by PET/CT.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Digestive System Diseases Fatty Liver Liver Diseases Non-Alcoholic Fatty Liver Disease Vascular Diseases

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Korea University Guro Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy patients for visiting routine medical check in our clinic

Exclusion criteria

  • History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
  • Diabetes
  • Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg)
  • Malignancy
  • Severe renal or hepatic disease
  • Subjects taking medications that might affect inflammation such as nonsteroidal antiinflammatory drug and statin

Treatment and study plan

Primary outcomes

  1. Correlation between vascular inflammatory status measured by 18FDG PET and NAFLD measured by un-enhanced CT

    Time frame: 12 weeks

  2. Correlation between vascular inflammatory status measured by 18FDG PET and epicardial adipose tissue measured by CT

    Time frame: 12 weeks

Secondary outcomes

  1. The relationship of NAFLD with carotid intima media thickness

    Time frame: 12 weeks

  2. The relationship of epicardial adipose tissue volume with carotid intima media thickness

    Time frame: 12 weeks

Sponsors and collaborators

Lead sponsor

Korea University

Other

Registry information

Important dates

Study start
2008
Primary completion
2011
First posted
Oct 9, 2013
Registry last updated
Oct 9, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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