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OpenTrials
Completed

NCT Number: NCT02394743

Correlation Between Estimated Glomerular Filtration Rate(eGFR) and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Renal insufficiency is close correlation with atherosclerosis and cardiovascular mortality.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between eGFR and vascular inflammation detected by 18F FDG-PET.

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Key information

Age range

30 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Internal Medicine, Korea University College of Medicine

Seoul, VD, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • absence of prior cancer diagnosis or remission from cancer at the time of PET imaging and throughout the follow-up period;
  • >=30 years of age;
  • no prior history of cardiovascular disease ; and
  • absence of acute or chronic inflammatory or autoimmune disease (based on documented medical history) or use of chronic anti-inflammatory therapy.

Exclusion criteria

  • age <35 years
  • presence of chronic inflammatory disease
  • use of anti-inflammatory medications
  • presence of active malignant cancer (defined as any radiological or pathological evidence of malignant cancer disease or undergoing chemotherapy or radiation therapy within 1 year before initial PET/CT and throughout the inter-scan duration).

Treatment and study plan

18FDG-PET

Radiation

Primary outcomes

  1. Correlation between vascular inflammatory status measured by 18F FDG-PET and eGFR by Modification of Diet in Renal Disease(MDRD) formula

    Time frame: at 1 day of taking 18F FDG - PET

Sponsors and collaborators

Lead sponsor

Korea University

Other

Registry information

Important dates

Study start
2011
Primary completion
2016
Study completion
2016
First posted
Mar 20, 2015
Registry last updated
Sep 8, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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