Correlation Between COVID-19 and Radiat… | Clinical Trial

Key information

Conditions

Breast Cancer Breast Diseases Breast Neoplasms COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Lung Diseases, Interstitial Lung Injury Neoplasms Neoplasms by Site Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Radiation Injuries Radiation Pneumonia Radiation Pneumonitis Respiratory Tract Diseases Respiratory Tract Infections Skin Diseases Skin and Connective Tissue Diseases Virus Diseases Wounds and Injuries

Age range

18 year–80 year

Sex eligibility

Female

Study type

Observational

Primary location

Zhejiang Hospital, Department of Oncology, Hangzhou, China, 310030

Hangzhou, Zhejiang, 310030, China

Location contact

Pengyuan Liu

CONTACT

[email protected]

18368846455

About this study

This study was designed as a single-center retrospective analysis aimed at investigating whether COVID-19 infection increases the risk or burden of radiation-induced pneumonitis in breast cancer patients. Breast cancer patients who underwent radiotherapy at the Cancer Center of Zhejiang Hospital between January 1, 2021, and June 30, 2024, were screened for eligibility. Patients who met the inclusion criteria were identified through the hospital information system, and their clinical records were reviewed. Follow-up was conducted via telephone interviews.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with pathologically or cytologically confirmed primary breast cancer,
aged 18 years or older but younger than 80 years,
with complete and reliable medical records,
for those with COVID-19 infection, documented evidence of a positive test result.

Exclusion criteria

concomitant pulmonary malignancies,
a history of prior thoracic radiotherapy,
concurrent pulmonary infections other than COVID-19 during radiotherapy,
missing key data with loss to follow-up,
or any other condition considered unsuitable for enrollment by the investigators.

Treatment and study plan

COVID-19

Other

The COVID-19 infection situation was used as an intervention measure, and the cohort was divided into groups.

Primary outcomes

Radiation Pneumonitis Situation

Time frame: From January 2021 to June 2024

The incidence rate, severity and onset time of radiation pneumonitis

Study contacts

Contact information is provided by the study sponsor or research team.

Pengyuan Liu

CONTACT

[email protected]

18368846455

Sponsors and collaborators

Lead sponsor

Zhejiang Hospital

Other

Registry information

Official study title

Correlation Between COVID-19 and Radiation Pneumonitis in Breast Cancer: A Historical Cohort Study

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Sep 23, 2025
Registry last updated: Sep 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed