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Completed

NCT Number: NCT01150019

Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) (18FDG-PET)

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis.Resistin was shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between circulating resistin and vascular inflammation detected by 18FDG-PET in obese persons.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Vascular Diseases

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hae Yoon Choi

Seoul, 152-703, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers for visiting routine medical check in our clinic

Exclusion criteria

  • History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
  • Diabetes
  • Hypertension
  • Malignancy
  • Severe renal or hepatic disease
  • Subjects taking medications that might affect inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) and statin

Treatment and study plan

Cross sectional study

Other

This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting

Primary outcomes

  1. Vascular inflammation in carotid arterial wall represented as the target-to-background ratio (TBR) using FDG-PET

    Time frame: 12 weeks

Secondary outcomes

  1. Circulating serum adiponectin levels

    Time frame: 12 weeks

  2. carotid intima-media thickness levels measured using ultrasonography

    Time frame: 12 weeks

  3. Circulating serum resistin levels

    Time frame: 12 weeks

Sponsors and collaborators

Lead sponsor

Korea University

Other

Registry information

Official study title

Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18FDG-PET in Obese Person

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
Jun 24, 2010
Registry last updated
Jul 8, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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