Correlation Between Aqueous Protein Level and Clinical Grading of Flare and Flaremetry.

The purpose of this study is to compare flaremetry readings with the protein content of the aqueous humor and the clinical grading of flare.

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Key information

Conditions

Uveitis Eye Diseases Uveal Diseases

Age range

10 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The Eye Center

Riyadh, Saudi Arabia

About this study

A total of 20 patients will be included. 10 patients with uveitis and 10 control patients scheduled for phacoemulsification. Each patient will undego complete ophthalmic examination and clinical biomicroscopic grading of the anterior chamber flare applying the SUN working group grading system. Aqueous specimens will be obtained by anterior chamber paracentesis for protein analysis. Each Patient will undego paracentesis and 0.2 ml of aqueous will be obtained. The aqueous sample will be stored at -70°C until the time of analysis for protein content. Objective assessment of flare will be done.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

10 patients with uveitis with cataract
10 patients without uveitis with cataract
Inactive inflammation for at least 3 months

Exclusion criteria

Infectious uveitis
endophthalmitis
cases with corneal scar

Treatment and study plan

Paracentesis of the anterior chamber

Procedure

Aqueous humor parenthesis for quantitative protein analysis in patients with and without uveitis.

Primary outcomes

compare flaremetry readings with the protein content of the aqueous humor

Time frame: one month

Compare flaremetry readings with the protein content of the aqueous and the clinical grading.

Sponsors and collaborators

Lead sponsor

The Eye Center and The Eye Foundation for Research in Ophthalmology

Other

Registry information

Important dates

Study start: 2013
Primary completion: 2013
Study completion: 2013
First posted: Jul 23, 2013
Registry last updated: Sep 1, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed