Correlation Between Advanced Glycation End Products and Gastric Motility Disorder in Diabetes Gastroparesis

This study will collect the gastric smooth muscle tissue and serum of patients with diabetic gastroparesis（DGP) and control group patients without diabetes history and gastroparesis symptoms, and collect the following patient related information: age, gender, height, weight, fasting blood glucose, diabetes course, glycosylated hemoglobin, fasting C-peptide, serum creatinine, and electrogastrogram results.

The study will compare the score of gastroparesis cardinal symptom index scale and electrogastrogram results of patients with DGP and and control group patients without diabetes history and gastroparesis symptoms, detect and compare the difference in the expression of contractile protein in the muscle layer of gastric tissue of the two groups, detect and compare the difference in advanced glycation end products (AGEs) of serum and gastric tissue of the two groups, and analyze the correlation between serum and gastric tissue AGEs and clinical symptoms. Through the above results, we will clarify the correlation between AGEs and gastric motility disorders in DGP.

Inclusion criteria

for diabetes gastroparesis group:

• Meet the diagnostic criteria for diabetes
• Presence of symptoms (see assessment of Gastroparesis Cardinal Symptom Index)
• Age range from 18 to 75 years old
• Voluntarily participate and sign an informed consent form

Inclusion criteria

for control group:

• No history of diabetes
• No symptoms (see assessment of Gastroparesis Cardinal Symptom Index)
• Age range from 18 to 75 years old
• Voluntarily participate and sign an informed consent form

Exclusion criteria

for diabetes gastroparesis group and control group:

• Currently taking prokinetic drugs, anticholinergic drugs, and dopamine drugs that may affect gastric motility
• Has a history of gastrointestinal surgery
• Pregnant or preparing to conceive
• There are neurological disorders such as Parkinson's disease that affect gastrointestinal function
• Outlet obstruction caused by organic lesions in the pylorus