Correction of Psoriatic T Cell Signatures by Deucravacitinib

This is a one-arm, open-label study to examine the effect of deucravacitinib on cutaneous and blood immune cells of psoriatic patients. 25 subjects with moderate to severe psoriasis will be enrolled. Biopsy and blood samples will be collected before and during treatment and undergo molecular profiling to assess for deucravacitinib-corrected signatures.

Inclusion criteria

• 18 years of age or older
• Patients with moderate-severe psoriasis (BSA >= 10%, PASI >=12, static Physician's Global Assessment (sPGA) 3 and above)

Exclusion criteria

• taking systemic immunosuppressives in the last 12 weeks
• pregnancy
• severe immunodeficiency (either from genetic or infectious causes).
• tuberculosis or other active serious infection
• active systemic malignancy.
• breast-feeding
• Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.