Coronary Microvascular Dysfunction in Angina Patients With Non-obstructive Coronary Artery Disease (ANOCA-CMD)

The goal of this observational study is to explore the incidence and effect on prognosis of coronary microvascular dysfunction in patients present of stable anginal symptoms, a clinical indication for invasive coronary angiography, and no hemodynamically significant epicardial coronary artery disease, defined as fractional flow reserve (FFR) >0.80.

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Key information

Conditions

Angina Patients With Non-obstructive Coronary Artery Disease Coronary Microvascular Dysfunction Index of Microvascular Resistance

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

China-Japan Friendship Hospital

Beijing, Beijing Municipality, 100029, China

Location status: Recruiting

Location contact

Jingang Zheng

CONTACT

[email protected]

01084205625

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

presence of stable anginal symptoms, a clinical indication for invasive coronary angiography, and no hemodynamically significant epicardial coronary artery disease, defined as fractional flow reserve (FFR) >0.80

Exclusion criteria

acute myocardial infarction
significant valvular heart disease
advanced chronic kidney disease
patients with significant epicardial coronary artery stenosis (>70% in major vessels by diagnostic coronary angiography) needing percutaneous coronary intervention
patients unable to provide written informed consent

Treatment and study plan

Primary outcomes

MACE in 12 months

Time frame: 12 months

major adverse cardiovascular events 12 months, including cardiac death, myocardial infarction, and readmission for angina.

Study contacts

Contact information is provided by the study sponsor or research team.

Zhaoxue Sheng, Doctor

CONTACT

[email protected]

+86-15600268925

Sponsors and collaborators

Lead sponsor

China-Japan Friendship Hospital

Other

Registry information

Official study title

Coronary Microvascular Dysfunction in Angina Patients With Non-obstructive Coronary Artery Disease

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2025
First posted: Jul 16, 2024
Registry last updated: Jul 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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