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Completed

NCT Number: NCT02494947

Coronary Disease and the Effect of High-intensity Interval Training

The primary purpose of this study is to investigate if systematic, high intensity, interval-based aerobic exercise training results in regression of lipid content of atherosclerotic coronary artery plaques, and in reduction of plaque burden in patients with stable coronary heart disease. Composition and morphologic characteristics of plaques will be studied by intra-coronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) in patients undergoing percutaneous coronary intervention.

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Key information

Conditions

Coronary Disease Behavior Cardiovascular Diseases Heart Diseases Motor Activity Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

St Olavs Hospital

Trondheim, Norway

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • stable coronary artery disease
  • will undergo cardiac catheterization
  • will be treated with percutaneous coronary intervention (PCI)
  • signed written informed consent
  • able to execute the intervention

Exclusion criteria

  • earlier bypass surgery
  • known inflammatory disease other than atherosclerosis
  • planned surgery within 4 months
  • included in another randomized controlled study

Treatment and study plan

high intensity interval-based aerobic exercise

Behavioral

Interval exercises done 3 times weekly during 6 months according to standard procedures at the Department of Circulation and Medical Imaging.

Usual Care

Other

Primary outcomes

  1. lipid content of atherosclerotic coronary artery plaques

    Time frame: 6 months

    Lipid core burden index (LCBI) measured by intracoronary near-infrared spectroscopy

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Collaborators

  • St. Olavs Hospital

Registry information

Official study title

Physical Activity and Lipid Content of Coronary Artery Atheromatous Plaques: a Randomised Trial Using Novel Intracoronary Imaging Techniques

Acronym: CENIT

Important dates

Study start
2016
Primary completion
2019
Study completion
2019
First posted
Jul 10, 2015
Registry last updated
Aug 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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