Coronary CT Angiography to Predict Vascular Events In Noncardiac Surgery patIents cOhort evaluatioN (CTA -VISION) Study

Worldwide 200 million adults annually undergo major noncardiac surgery and 5 million of these patients will suffer a major vascular complication. Despite the magnitude of this problem our capacity to predict these events is limited. Although perioperative myocardial infarction (MI) is the most common major perioperative cardiac complication, little is known about its pathophysiology. Coronary computed tomography angiography (CTA) is a potential non-invasive method for the detection of coronary artery disease and cardiac risk stratification in the non-operative setting; however, the value of this test to enhance risk prediction among patients scheduled for noncardiac surgery is unknown. This study is an international prospective cohort study to determine among patients with, or at risk of, atherosclerotic disease who are undergoing noncardiac surgery: 1) if preoperative coronary CTA has additional predictive value for the occurrence of major perioperative cardiac events and 2) the underlying coronary anatomy associated with perioperative MIs.

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Key information

Conditions

Cardiovascular Disease Cardiovascular Diseases

Age range

45 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Juravinski Hospital

Hamilton, Ontario, L8V5C2, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age >=45 years
undergoing non cardiac surgery requiring an overnight stay and general or regional anaesthetic
at least one of:

Coronary Artery Disease (CAD)
Peripheral Vascular Disease (PVD)
History of Stroke
History of Congestive Heart Failure (CHF)
Combination of at least 3 of:
age >= 70 years
history of treatment for hypertension
history of treatment for dyslipidemia
smoking in last 2 years
diabetic and currently taking insulin or oral diabetic drugs
history of Transient Ischemic Attack (TIA)

Exclusion criteria

contraindications to CTA

Treatment and study plan

Coronary CT Angiogram

Other

pre-operative coronary CTA

Primary outcomes

Perioperative MI

Time frame: 30-days post-operative

Secondary outcomes

Perioperative Cardiovascular Event

Time frame: 30-days post-operative

Sponsors and collaborators

Lead sponsor

Canadian Institutes of Health Research (CIHR)

Other Gov

Registry information

Acronym: CTA-VISION

Important dates

Study start: 2007
Primary completion: 2014
Study completion: 2014
First posted: Jul 9, 2012
Registry last updated: Apr 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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