Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry

The overall objective of CONFIRM2 is to perform the largest cardiovascular phenotype outcomes study ever.

Enrolling by Invitation

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Virginia

Charlottesville, Virginia, 22904, United States

About this study

CONFIRM2 is a retrospective and prospective, open-label, international, multicenter observational registry designed to evaluate associations between CCTA imaging findings and clinical presentation (cross-sectional) and their ability to predict mortality and major adverse cardiac events (longitudinal) in patients with chronic CAD.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age >18 years
Undergoing clinically indicated CCTA with >64-detector row CT
Signed informed consent, including of release of medical information, long term follow-up and Health Insurance Portability and Accountability Act (HIPAA) documentation

Exclusion criteria

Individuals unable to provide informed consent
Non-cardiac illness with life expectancy < 2 years
Pregnancy

Treatment and study plan

Primary outcomes

Coronary CT Angiography EvaluatioN For Clinical Outcomes

Time frame: June 2020- June 2022

Examined the totality of information visualized by coronary CT angiography (CCTA) for optimal refinement of prognostic risk stratification

Sponsors and collaborators

Lead sponsor

Cleerly, Inc.

Industry

Registry information

Official study title

Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter

Acronym: CONFIRM2

Important dates

Study start: 2020
Primary completion: 2027
Study completion: 2027
First posted: Feb 21, 2020
Registry last updated: Jun 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Enrolling by Invitation