Coronary Atherosclerosis Evaluation by Arterial Wall Magnetic Resonance Imaging (MRI)

The overall goal of this study is to use MRI to:

* Examine the relationship between known risk factors for cardiovascular disease and coronary artery wall thickness; * Examine the relationship between coronary artery wall thickness and other markers of subclinical coronary atherosclerosis, such as carotid wall thickness and coronary calcium scores; and, * Examine the feasibility of measuring the progression of coronary artery wall thickness over time in a subset of participants.

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Key information

Conditions

Coronary Arteriosclerosis Arterial Occlusive Diseases Arteriosclerosis Arteriosclerosis, Coronary Atherosclerosis Atherosclerosis, Coronary Cardiovascular Diseases Coronary Artery Disease Coronary Atherosclerosis Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

45 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Northwestern University MESA Field Center, Chicago, Illinois, United States

About this study

Each enrolled participant will undergo MR Imaging of the coronary arteries in conjunction with their routine MESA follow-up visit. The MRI will last approximately 45-60 minutes

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Prior enrollment in the MESA Study at the Hopkins MESA Field Center or the Northwestern University MESA Field Center
Male or Female adult equal to or older than 45 years of age
Willing/able to provide informed consent

Exclusion criteria

Any known contraindications to MRI (i.e. severe claustrophobia, pacemaker, etc.)
Metal in the eyes

Treatment and study plan

MR Imaging of the Coronary Arteries

Procedure

Primary outcomes

Mean Coronary Wall Thickness

Time frame: n/a (cross sectional analysis)

Average thickness of the wall of the left anterior descending, right and left main coronary artery measured by magnetic resonance imaging (MRI).

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Collaborators

Northwestern University

Registry information

Official study title

Coronary Atherosclerosis Evaluation by Arterial Wall MRI

Important dates

Study start: 2005
Primary completion: 2008
Study completion: 2008
First posted: Jul 19, 2006
Registry last updated: Jun 22, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed