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NCT Number: NCT06746467

Corneal Topography in Vernal Keratoconjunctivitis

To evaluate the corneal topographic changes in VKC patients using Pentacam and prevalence of KC development in VKC.

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Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

Vernal keratoconjunctivitis (VKC) is a chronic allergic disease, with seasonal periods of exacerbation.VKC is characterized by itching, photophobia. white mucous discharge, lacrimation, foreign body sensation, and pain due to corneal involvement of shield ulcers. Corneal involvement in VKC involves injury to the superficial and basal epithelial layers and anterior stroma . Excessive eye rubbing and a slow release of matrix metalloproteinases penetrate the cornea in presence of chronic epithelial damage causing astigmatism and corneal ectasia . These changes may be undetected until advanced complications such as keratoconus(KC) with thinning and protrusion of cornea leading to myopia and astigmatism . These changes can be measured accurately by corneal topography, making it the gold standard in the screening of keratoconus and other corneal ectasias . Corneal topography is a method of computer-assisted examination of the cornea in which multiple concentric light rings are projected on cornea. Changes in corneal topography indices to be studied include changes in effective refeactivepower ,asphericity , corneal asymmetry index and visual performance . It is a non-invasive exploratory technique to analyse both qualitatively and quantitatively the morphology of the cornea . The Penta Cam is a cornea and anterior segment topography device, based on a rotating Scheimpflug camera. Its optical cross-sectional analysis that helps in imaging of anterior and posterior corneal surfaces which provides with fullpachymetric map and many other data such as corneal aberrometry and densitometry that allow early detection of ectasia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

clinical diagnosis of vernal keratoconjunctivitis -

Exclusion criteria

patients with corneal disease as corneal opacity, corneal dystrophy or degenerative changes patients with previous corneal surgery patients with ocular trauma.

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Treatment and study plan

pentacam

Device

evaluate corneal changes by pentacam

Primary outcomes

  1. evaluate the corneal topographic changes in VKC patients using Pentacam

    Time frame: 1 year

Secondary outcomes

  1. prevalence of KC development in VKC

    Time frame: 1 year

Study contacts

Contact information is provided by the study sponsor or research team.

dalia mohamed mohamed, professer

CONTACT

+201223212962

monica basem fayez, doctor

CONTACT

[email protected]

+201202961139

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

the Effect of Vernal Keratoconjunctivitis on Corneal Topographic Profiles

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 24, 2024
Registry last updated
Dec 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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