Corneal Endothelium Cell Loss After Cataract Extraction in Patients Taking Tamsulosin

The purpose of this study is to determine whether corneal endothelium cell loss during cataract surgery is higher in patients taking Tamsulosin.

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Key information

Conditions

Cataract Eye Diseases Lens Diseases

Sex eligibility

Male

Study type

Observational

Primary location

Frederiksberg University Hospital

Frederiksberg, 2000, Denmark

About this study

Cataract surgery in patients taking Tamsulosin is regarded as more challenging for the surgeon because Intraoperative Floppy Iris Syndrome (IFIS) might occur. However, the question is whether this has any practical implication for the outcomes of surgery. In this study we investigate whether cornea is damage during surgery on Tamsulosin patient. In an observational study 30 cataract patients taking Tamsulosin is compared to 30 patients not taking Tamsulosin, but otherwise similar. Number of patients is based on power calculation.

Cornea is examined by specular microscopy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

cataract needing surgery

Exclusion criteria

glaucoma
corneal scarring
diabetes
uveitis

Treatment and study plan

Primary outcomes

corneal endothelium cell loss

Time frame: 3 months

Corneal endothelium cells was evaluated by specular microskopy before and 3 month post-operatively.

Sponsors and collaborators

Lead sponsor

Frederiksberg University Hospital

Other

Registry information

Official study title

Corneal Endothelium Cell Loss After Cataract Extraction in Patients Taking Systemic Sympathetic Alfa-1-a-antagonist Medication (Tamsulosin)

Important dates

Study start: 2009
Primary completion: 2010
Study completion: 2010
First posted: Feb 26, 2010
Registry last updated: Jul 21, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed