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Completed

NCT Number: NCT05447130

Corneal Endothelium After Phacoemulsification in Pseudo Exfoliation Syndrome

To study corneal endothelial cells changes after phacoemulsification in patients with senile cataract and pseudoexfoliation syndrome (PEX) compared with control patients with senile cataract using specular microscope.

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Key information

Conditions

Corneal Endothelial Cell Loss Cataract Corneal Diseases Exfoliation Syndrome Eye Diseases Eye Manifestations Iris Diseases Lens Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Pseudoexfoliation Syndrome Signs and Symptoms Uveal Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Minia University Hospital

Minya, Minya Governorate, 61111, Egypt

About this study

In a prospective interventional case-control study, 20 eyes with cataract and PEX and 20 control eyes with cataract without PXE were subjected to phacoemulsification and posterior chamber foldable intraocular lens implantation in Minia University Hospital and Genaidy Eye Center between March 2019 and December 2020. Specular microscopy was done preoperatively, 3 and 6 months postoperatively. Endothelium cell density (ECD), coefficient variation (CV), hexagonality, pleomorphism and corneal thickness were evaluated and compares between PXE and control eyes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • senile cataract age more than 55 years

Exclusion criteria

  • PEX with glaucoma, eyes with cornea guttata or any corneal dystrophy, zonular dehiscence, very dense nuclear cataract (cataracta nigra) history of previous ocular surgery.

Treatment and study plan

phacoemulsification

Procedure

phacoemulsification with corneal endothelial evaluation by specular microscopy

Primary outcomes

  1. corneal endothelial cell loss

    Time frame: 6 months

    corneal endothelial cell loss

Sponsors and collaborators

Lead sponsor

Minia University

Other

Registry information

Official study title

Corneal Endothelial Evaluation After Phacoemulsification in Eyes With Pseudoexfoliation Syndrome

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Jul 7, 2022
Registry last updated
Sep 13, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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