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NCT Number: NCT07418606

Corneal Endothelial Cell Changes In Silicon Filled Eye

The aim of this study is to evaluate corneal endothelial cell changes after pars plana vitrectomy in Rhegmatogenous Retinal detachment , compare the results using different silicon oil viscositites , and assess whether these changes are reversible after silicone removal or not .

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Rhegmatogenous Macula-off Retinal Detachment

Sex eligibility

All sexes

Study type

Observational

Primary location

Minia University

Minya, 61111, Egypt

About this study

The aim of this study is to evaluate corneal endothelial cell changes after pars plana vitrectomy in Rhegmatogenous Retinal detachment , compare the results using different silicon oil viscositites , and assess whether these changes are reversible after silicone removal or not .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients with Rhegmatodenous retinal detachment which need PPV will be included in this study.

Exclusion criteria

  • Patients with corneal dystrophies or degeneration.
  • Patients with a history of refractive surgery, either corneal or phakic lOL implantation.
  • Patients with a history of keratoplasty.
  • Patients with history of retinal detachment surgery in the same eye.
  • Recurrent cases during the follow-up period will be removed from the study. 6. patients with gas tamponade 7. patients with silicon oil 1000 cs 8. patients with Retinal pathologies such as macular hole , diabetic changes 9. patients undergo phacovitrectomy

Treatment and study plan

Primary outcomes

  1. Corneal Endothelial Cell Changes In Silicon Filled Eye .

    Time frame: 4 months

    Corneal Endothelial Cell Changes cell density ( cells/ mm) , coeffient variation(%) In Silicon Filled Eye at 1 and 3 months postoperative

Sponsors and collaborators

Lead sponsor

Minia University

Other

Registry information

Acronym: Endothelium

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 18, 2026
Registry last updated
Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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