Corneal Autograft for Limbal Dermoid

Inclusion criteria

• Age between 5 to 35 years old,
• Patients with limbal dermoid, scheduled for elective surgical excision,
• The distance of less than 5 mm of lesion encroachment into the cornea,
• The participant or their legal guardian has voluntarily chosen to participate in this study, has signed the informed consent form, and has demonstrated a high level of adherence to the study protocols and cooperation throughout the follow-up process.

Exclusion criteria

• Keratoconus,
• High myopia with a spherical equivalent of -15.0 D or less,
• Ocular and facial active inflammation such as keratitis, trachoma, dacryocystitis, blepharitis, meibomian gland dysfunction, Sjogren's syndrome, cicatricial pemphigoid etc,
• Corneal or ocular surface infection within 30 days prior to study entry,
• Severe cicatricial eye disease,
• Ocular surface malignancy,
• Ocular comorbidities that affect the prognosis of transplantation, such as advanced glaucoma or retinal diseases,
• History of allo-limbal transplantation, penetrating keratoplasty or anti-glaucoma filtering surgeries,
• Uncontrolled diabetes with most recent Hemoglobin A1c greater than 8.5%,
• Renal failure with creatinine clearance< 25ml/min,
• Alanine aminotransferase > 40IU/L, or aspartate aminotransferase > 40IU/L,
• Platelet levels < 150,000 or > 450,000 per microlite,
• Hemoglobin < 12.0 g/dL (male) or < 11.0 g/dL (female),
• Prothrombin time > 16s and activated partial thrombin time > 35s in patients not accepting anticoagulant therapy, An international normalized ratio greater than 3 in patients accepting anticoagulant therapy,
• Pregnancy (positive test) or lactation,
• Active immunological diseases,
• Signs of current infection, including fever and treatment with antibiotics,
• Participation in another simultaneous medical investigation or clinical trial.