Texas A&M University
College Station, Texas, 77843, United States
NCT Number: NCT05395390
This study is being done to understand body's response to hybrid home-based and on-site rehabilitation program utilizing individually tailored exercises throughout a total of 18 sessions with 12 of them occurring onsite, in people with and without chronic respiratory diseases, such as Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) and in individuals recovered from COVID-19. Exercise training programs vary widely for people with COPD, OSA, and during prolonged recovery from COVID infection. This study will help identify if this program is helpful to address muscle loss and fatigue specifically in populations with and without chronic respiratory diseases.
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Notify Me30 year–85 year
All sexes
Interventional
Not applicable
College Station, Texas, 77843, United States
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
-or- Obstructive Sleep Apnea (OSA)
-or- 2 weeks post-recovered* from laboratory confirmed case of COVID
● Willingness and ability to comply with the protocol
*Recovered is defined according to Brazos County Health District as someone who has been fever-free for 24 hours without fever-reducing medications, and it has been 10 days after onset of symptoms.
Inclusion criteria
control subjects
Exclusion criteria
Resistance Training done both at home and on site using either dumbells or keiser pneumatic exercise machines respectively
Time frame: up to 8 weeks Exercise Intervention
Whole-body production rate measured after stable tracer administration
Time frame: up to 8 week Exercise Intervention
Measurement of bone mineral density (g/cm^2)between COPD patients and healthy older adults using DXA
Time frame: up to 8 week Exercise Intervention
Measurement of muscle mass (kg)
Time frame: up to 8 week Exercise Intervention
Measurement of fat mass (kg)
Time frame: up to 8 week Exercise Intervention
Differences in muscle mass (kg), fat mass (kg), and extra- and intracellular fluid (L) between COPD patients and healthy older adults using BIA.
Time frame: up to 8 week Exercise Intervention
Difference and changes in handgrip strength pre and post exercise
Time frame: up to 8 week Exercise Intervention
With this sub-maximal exercise test, aerobic capacity and endurance will be compared between COPD patients and healthy older adults. The outcome is the distance covered over a time of 6 minutes.
Time frame: up to 8 week Exercise Intervention
Difference in muscle strength of leg using kin-com machine between pre and post exercise intervention.
Time frame: up to 8 week Exercise Intervention
Differences and changes in the concentration of the inflammatory marker C-reactive protein
Time frame: up to 8 week Exercise Intervention
In Part A, the examinee is instructed to connect a set of 25 circles with numbers as quickly as possible while maintaining accuracy. In Part B, the examinee is instructed to connect a set of 25 circles, alternating between numbers and letters, as quickly as possible while maintaining accuracy. Measures attentional resources and is a measure of the frontal lobe "executive" functions of visual search, set-switching and mental flexibility. The total time in seconds will be recorded for each measure.
Time frame: up to 8 week Exercise Intervention
A word page with words printed in black ink, a color page with blocks printed in color, and a color-word page where the color and the word do not match. The examinee reads the words or names the ink colors as quickly as possible within a time limit. Measures selective attention and inhibitory control. The total time in seconds was reported for each trial.
Time frame: up to 8 week Exercise Intervention
Self-administered questionnaire regarding gut function and associated symptoms. It is composed of 15 items (7-Point Likert Scale) assessing Reflux, Abdominal pain, Indigestion, Diarrhoea and Constipation. Scores range from 15 to 105 with a higher score indicating more discomfort.
Time frame: up to 8 week Exercise Intervention
Self-administered questionnaire is intended for use in an elderly population and focuses on 3 types of activities: leisure time activities, household activities and work-related activities.
Time frame: up to 8 week Exercise Intervention
A fourteen item self-assessment scale. Seven of the items related to anxiety and seven relate to depression. Each item on the questionnaire is scored from 0-3 and this means that a person can score between 0 (no symptoms) and 21 (severe symptoms) for either anxiety or depression.
Time frame: up to 8 week Exercise Intervention
Self-administered questionnaire regarding impact of COPD on daily life
Time frame: up to 8 week Exercise Intervention
The subject is asked to note in detail all the food and drinks consumed during 3 days (2 week days and 1 weekend day) in the week prior to each test day.
Time frame: up to 8 week Exercise Intervention
Recall of numbers in the same order (Digit Forward) and in reverse order (Digit Backward). Measures auditory attention and verbal working memory.
Time frame: up to 8 week Exercise Intervention
Assesses several cognitive domains and is used for the screening of mild cognitive impairment. Total scores range from 0-30 with lower scores indicating decreased functioning.
Time frame: up to 8 week Exercise Intervention
A psychological distress scale to measure mood disturbance in 6 domains - fatigue-inertia, vigor-activity, tension-anxiety, depression-dejection, anger-hostility, and confusion-bewilderment.
Time frame: up to 8 week Exercise Intervention
The examinee is required to say as many words as they can think of in one minute that begin with a given letter of the alphabet. The task contains three trials. Measures phonemic verbal fluency. The raw score (total and mean words recorded across the three trials) will be reported.
Time frame: up to 8 week Exercise Intervention
Quality of life concerns related to fatigue will be assessed only in COPD patients with this questionnaire.
Time frame: up to 8 week Exercise Intervention
Changes in Peak Power and Strength measured through testing completed using Keiser Pneumatic Resistance Training Devices
Texas A&M University
Other
Circuit-Exercise Training on Subjects With and Without Chronic Respiratory Disease
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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