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OpenTrials
Completed

NCT Number: NCT05722665

Convolutional Neural Network Model to Detect Coronavirus Disease 2019 (COVID-19) Pneumonia in Chest Radiographs

This study aims to design a Convolutional Neural Network (CNN) and apply an attention model to help differentiate pneumonia due to Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), pneumonia due to other viruses/bacteria, and normal chest x-ray (CXR) in clinical practice. A bank of digital chest images from a high-complexity health facility in Cali, Colombia, was used.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fundacion Valle del Lili

Cali, Valle del Cauca Department, 760001, Colombia

About this study

To differentiate coronavirus disease 2019 (COVID-19) pneumonia from other types of pneumonia, expert radiologists must analyze the chest x-ray (CXR) to identify visual, radiographic patterns associated with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It is challenging because the findings are similar for different types of pneumonia.

Since the manual diagnosis of COVID-19 from CXR is a difficult and time-consuming process, applying deep learning (DL) models to medical image analysis is a current hot research topic. This work will develop a new Convolutional Neural Network (CNN) to detect COVID-19 radiographs. It will use a large dataset of chest radiographs classified into three classes: viral/bacterial pneumonia, COVID-19 pneumonia, and normal images. The study aims to incorporate a new attention module that applies CNNs to the linear projection operation to help differentiate COVID-19 pneumonia from other pneumonia and normal chest radiographs in clinical practice.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chest radiographs from patients without COVID-19 or other pneumonia took before the pandemic start date (January 2020)
  • Chest radiographs from patients with COVID-19 confirmed by positive Reverse Transcriptase polymerase chain reaction (RT-PCR) and/or presence of antibodies to COVID-19 and/or positive COVID-19 viral antigen.
  • Chest radiographs from patients without COVID-19 confirmed by a negative Reverse Transcriptase polymerase chain reaction (RT-PCR) and other pneumonia diagnoses taken before the pandemic start date (January 2020)

Exclusion criteria

  • N/A

Treatment and study plan

Categorization of chest xrays images

Other

Use of Convolutional Neural Network Model to categorize chest xrays images in each group.

Primary outcomes

  1. COVID-19 (coronavirus disease 2019) pneumonia chest radiograph identified

    Time frame: month 8

    Development and determination of the predictive capacity of a Convolutional Neural Network model to detect viral pneumonia in chest radiographs of adult patients with acute respiratory disease secondary to SARS-COV-2 infection.

Sponsors and collaborators

Lead sponsor

Fundacion Clinica Valle del Lili

Other

Collaborators

  • Universidad Autonoma de Occidente

Registry information

Official study title

The Predictive Capacity of a Convolutional Neural Network (CNN) Model to Detect Viral Pneumonia in Adult Patients With Coronavirus Disease 2019 (COVID-19) in Cali, Colombia

Acronym: RedNeumon

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Feb 10, 2023
Registry last updated
Feb 23, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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